| Literature DB >> 14640519 |
V S Prakash Chaturvedula1, Zhijie Gao, Sidney M Hecht, Shannon H Jones, David G I Kingston.
Abstract
Bioassay-directed fractionation of a n-hexane extract of Couepia polyandra using an assay to detect inhibitors of the lyase activity of DNA polymerase beta resulted in the isolation of the new triterpene 3beta,16beta,23-triacetoxyolean-12-en-28-oic acid (1) and four known compounds, oleanolic acid, betulinic acid, stigmasterol, and beta-sitosterol. The structure of the new compound was established on the basis of extensive 1D and 2D NMR spectroscopic interpretation. All five compounds inhibited DNA polymerase beta lyase activity.Entities:
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Year: 2003 PMID： 14640519 DOI： 10.1021/np0301893
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050