| Literature DB >> 14640518 |
Curtis C Barnes1, Mary K Smalley, Kirk P Manfredi, Kelly Kindscher, Hillary Loring, Douglas M Sheeley.
Abstract
The organic soluble extract from the leaves of the native North American prairie plant Ipomoea leptophylla (big root morning glory) showed in vitro activity against M. tuberculosis. Bioassay-guided fractionation of this extract resulted in the identification of two new resin glycosides (6, 7). Base-catalyzed hydrolysis of these glycosides gave operculinic acid (1) as the glycosidic acid component as well as trans-cinnamic acid, propanoic acid, and lauric acid. The complete structure elucidation was accomplished through derivatization, 1D and 2D NMR spectroscopy (TOCSY, ROESY, HSQC, HMBC), and MS/MS experiments on 6 and 7 as well as the permethylated derivative 8.Entities:
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Year: 2003 PMID： 14640518 DOI： 10.1021/np030197j
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050