| Literature DB >> 14640511 |
Fang-Rong Chang1, Ken-Ichiro Hayashi, I-Hsiao Chen, Chih-Chuang Liaw, Kenneth F Bastow, Yuka Nakanishi, Hiroshi Nozaki, Gordon M Cragg, Yang-Chang Wu, Kuo-Hsiung Lee.
Abstract
Twenty-one compounds, including five new agarofuran sesquiterpenes, reissantins A-E (1-5), were isolated from Reissantia buchananii by means of bioassay-directed fractionation and their structures identified from spectral data. Reissantins A-C are the first reported simple agarofuran sesquiterpenes to contain a 5-carboxy-N-methyl-2-pyridone (CNMP) substituent, which has previously been found only in macroring agarofuran pyridine alkaloids. The major terpenoid components, celastrol (6) and its methyl ester derivative, pristimerin (7), were significantly active against nine cancer cell lines, including A549, MCF-7, HCT-8, KB, KB-VIN, U-87-MG, PC-3, 1A9, and PTX10 cell lines, with ED(50) values ranging from 0.076 to 0.34 microg/mL.Entities:
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Year: 2003 PMID： 14640511 DOI： 10.1021/np030241v
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050