| Literature DB >> 14639604 |
Eiji Suzuki1, Tetsuya Ota, Kazunori Tsukuda, Atsushi Okita, Kinya Matsuoka, Masakazu Murakami, Hiroyoshi Doihara, Nobuyoshi Shimizu.
Abstract
The nm23-H1 gene is known as a potential metastasis suppressor gene in various types of carcinomas. However, the role of nm23-H1 in colorectal carcinoma still remains controversial and the cellular mechanisms by which its protein may modulate the metastatic phenotype are not yet known. We transfected nm23-H1 cDNA into the human colon cancer cell line, HT-29, to test the effects and cellular biological mechanism of nm23 protein in colon cancer. We found that nm23-H1 strongly inhibited the liver metastasis of HT-29 cells in nude mice and inhibited the epidermal growth factor (EGF)-induced cell migration in vitro. Furthermore, we clarified the regulation of the myosin light chain (MLC) phosphorylation by nm23-H1, which has been demonstrated as having potential role in cell migration. Copyright 2003 Wiley-Liss, Inc.Entities:
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Year: 2004 PMID： 14639604 DOI： 10.1002/ijc.11546
Source DB: PubMed Journal: Int J Cancer ISSN： 0020-7136 Impact factor: 7.396