Literature DB >> 14638998

Two different scrapie prions isolated in Japanese sheep flocks.

Yasuhiro Hirogari1, Masanori Kubo, Kumiko M Kimura, Makoto Haritani, Takashi Yokoyama.   

Abstract

Two different scrapie prion strains with different characteristics were obtained from two sheep naturally infected with scrapie in Japan. In mice transmission, one (Tsukuba-1) showed shorter incubation periods (133+/-2 days) than the other (Tsukuba-2) (288+/-5 days). Spongiform changes and accumulation of an abnormal isoform of prion protein (PrP(Sc)) were observed throughout the brain in Tsukuba-1 inoculated mice, while the lesions and the PrP(Sc) accumulation were localized in the brain stem of mice with Tsukuba-2. Western blot analysis showed that there was no strain-specific glycoform of PrP(Sc) within these two strains. A super-infection experiment revealed that neither strain interfered with the other's propagation.

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Year:  2003        PMID： 14638998     DOI： 10.1111/j.1348-0421.2003.tb03453.x

Source DB:  PubMed          Journal:  Microbiol Immunol        ISSN： 0385-5600            Impact factor:   1.955


  8 in total

1.  Atypical/Nor98 scrapie in the Basque Country: a case report of eight outbreaks.

Authors:  Ana B Rodríguez-Martínez; Joseba M Garrido; Sonia Maza; Leyre Benedicto; Mariví Geijo; Nieves Gómez; Esmeralda Minguijón; Sylvie L Benestad; Ramón A Juste
Journal:  BMC Vet Res       Date:  2010-03-26       Impact factor: 2.741

2.  Biological and biochemical characterization of L-type-like bovine spongiform encephalopathy (BSE) detected in Japanese black beef cattle.

Authors:  Kentaro Masujin; Yujing Shu; Yoshio Yamakawa; Ken'ichi Hagiwara; Tetsutaro Sata; Yuichi Matsuura; Yoshifumi Iwamaru; Morikazu Imamura; Hiroyuki Okada; Shirou Mohri; Takashi Yokoyama
Journal:  Prion       Date:  2008-07-14       Impact factor: 3.931

3.  Prion subcellular fractionation reveals infectivity spectrum, with a high titre-low PrPres level disparity.

Authors:  Victoria Lewis; Cathryn L Haigh; Colin L Masters; Andrew F Hill; Victoria A Lawson; Steven J Collins
Journal:  Mol Neurodegener       Date:  2012-04-26       Impact factor: 14.195

4.  Blocking of FcR suppresses the intestinal invasion of scrapie agents.

Authors:  Ryuta Uraki; Akikazu Sakudo; Kosuke Michibata; Yasuhisa Ano; Jyuri Kono; Masayoshi Yukawa; Takashi Onodera
Journal:  PLoS One       Date:  2011-03-18       Impact factor: 3.240

5.  Heterogeneity of the Abnormal Prion Protein (PrPSc) of the Chandler Scrapie Strain.

Authors:  Kazuo Kasai; Yoshifumi Iwamaru; Kentaro Masujin; Morikazu Imamura; Shirou Mohri; Takashi Yokoyama
Journal:  Pathogens       Date:  2013-02-18

6.  Selective propagation of mouse-passaged scrapie prions with long incubation period from a mixed prion population using GT1-7 cells.

Authors:  Kohtaro Miyazawa; Kentaro Masujin; Hiroyuki Okada; Yuko Ushiki-Kaku; Yuichi Matsuura; Takashi Yokoyama
Journal:  PLoS One       Date:  2017-06-21       Impact factor: 3.240

7.  Isolation of two distinct prion strains from a scrapie-affected sheep.

Authors:  Kentaro Masujin; Yujing Shu; Hiroyuki Okada; Yuichi Matsuura; Yoshifumi Iwamaru; Morikazu Imamura; Shirou Mohri; Takashi Yokoyama
Journal:  Arch Virol       Date:  2009-10-30       Impact factor: 2.574

8.  Susceptibility of GT1-7 cells to mouse-passaged field scrapie isolates with a long incubation.

Authors:  Kohtaro Miyazawa; Hiroyuki Okada; Yoshifumi Iwamaru; Kentaro Masujin; Takashi Yokoyama
Journal:  Prion       Date:  2014       Impact factor: 3.931
  8 in total

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