Literature DB >> 14638808

Interleukin-10 and pathogenesis of murine ocular toxoplasmosis.

Fangli Lu1, Shiguang Huang, Lloyd H Kasper.   

Abstract

To understand the role of interleukin-10 (IL-10) in ocular toxoplasmosis, we compared C57BL/6 (B6) and BALB/c background mice lacking a functional IL-10 gene (IL-10(-/-)) and B6 transgenic mice expressing IL-10 under the control of the IL-2 promoter. Increased cellular infiltration and necrosis were observed in the eye tissue of IL-10(-/-) mice of both the B6 and BALB/c backgrounds with associated changes in the levels of cytokines in serum. In contrast, there was no evidence of necrosis in the eye tissue from IL-10 transgenic mice following parasite exposure. Our results demonstrate that IL-10 is important in the regulation of inflammation during acute ocular toxoplasmosis.

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Year:  2003        PMID： 14638808      PMCID： PMC308941          DOI： 10.1128/IAI.71.12.7159-7163.2003

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  21 in total

1.  In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12, IFN-gamma and TNF-alpha.

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Journal:  J Immunol       Date:  1996-07-15       Impact factor: 5.422

2.  A protective role for endogenous tumor necrosis factor in Toxoplasma gondii infection.

Authors:  L L Johnson
Journal:  Infect Immun       Date:  1992-05       Impact factor: 3.441

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Journal:  Infect Immun       Date:  1997-05       Impact factor: 3.441

4.  Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells.

Authors:  H Groux; M Bigler; J E de Vries; M G Roncarolo
Journal:  J Immunol       Date:  1998-04-01       Impact factor: 5.422

5.  Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

Authors:  R T Gazzinelli; S Hieny; T A Wynn; S Wolf; A Sher
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

6.  Cytokine control of parasite-specific anergy in human urinary schistosomiasis. IL-10 modulates lymphocyte reactivity.

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Journal:  J Immunol       Date:  1996-06-15       Impact factor: 5.422

7.  Cytokine mRNA in the central nervous system of SCID mice infected with Toxoplasma gondii: importance of T-cell-independent regulation of resistance to T. gondii.

Authors:  C A Hunter; J S Abrams; M H Beaman; J S Remington
Journal:  Infect Immun       Date:  1993-10       Impact factor: 3.441

8.  Interleukin 10 production correlates with pathology in human Leishmania donovani infections.

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Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

Review 9.  Interleukin-10.

Authors:  R de Waal Malefyt; H Yssel; M G Roncarolo; H Spits; J E de Vries
Journal:  Curr Opin Immunol       Date:  1992-06       Impact factor: 7.486

10.  Polymorphisms in the tumor necrosis factor alpha (TNF-alpha) gene correlate with murine resistance to development of toxoplasmic encephalitis and with levels of TNF-alpha mRNA in infected brain tissue.

Authors:  Y R Freund; G Sgarlato; C O Jacob; Y Suzuki; J S Remington
Journal:  J Exp Med       Date:  1992-03-01       Impact factor: 14.307
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  12 in total

1.  Experimental ocular toxoplasmosis in genetically susceptible and resistant mice.

Authors:  Fangli Lu; Shiguang Huang; Mark S Hu; Lloyd H Kasper
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

2.  IL-33/ST2 involves the immunopathology of ocular toxoplasmosis in murine model.

Authors:  Xinxin Tong; Fangli Lu
Journal:  Parasitol Res       Date:  2015-02-20       Impact factor: 2.289

3.  LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.

Authors:  Nannan Gao; Chong Wang; Yiran Yu; Linding Xie; Yien Xing; Yuan Zhang; Yanling Wang; Jianjun Wu; Yihong Cai
Journal:  PLoS Negl Trop Dis       Date:  2022-10-07

4.  CD4+ T cells in the pathogenesis of murine ocular toxoplasmosis.

Authors:  Fangli Lu; Shiguang Huang; Lloyd H Kasper
Journal:  Infect Immun       Date:  2004-09       Impact factor: 3.441

5.  CD4 T-cell suppression by cells from Toxoplasma gondii-infected retinas is mediated by surface protein PD-L1.

Authors:  Elizabeth Charles; Sunil Joshi; John D Ash; Barbara A Fox; A Darise Farris; David J Bzik; Mark L Lang; Ira J Blader
Journal:  Infect Immun       Date:  2010-05-24       Impact factor: 3.441

6.  Experimental Models of Ocular Infection with Toxoplasma Gondii.

Authors:  Agata Dukaczewska; Roberto Tedesco; Oliver Liesenfeld
Journal:  Eur J Microbiol Immunol (Bp)       Date:  2015-12-04

7.  Association of TREM-1, IL-1β, IL-33/ST2, and TLR Expressions With the Pathogenesis of Ocular Toxoplasmosis in Mouse Models on Different Genetic Backgrounds.

Authors:  Yanxia Zhang; Jian He; Huanqin Zheng; Shiguang Huang; Fangli Lu
Journal:  Front Microbiol       Date:  2019-10-09       Impact factor: 5.640

8.  Murine Model of Primary Acquired Ocular Toxoplasmosis: Fluorescein Angiography and Multiplex Immune Mediator Profiles in the Aqueous Humor.

Authors:  Kexin Li; Xue Feng; Kenji Hikosaka; Kazumi Norose
Journal:  Invest Ophthalmol Vis Sci       Date:  2021-03-01       Impact factor: 4.799

9.  Mast cells modulate acute toxoplasmosis in murine models.

Authors:  Bo Huang; Shiguang Huang; Ying Chen; Huanqin Zheng; Jilong Shen; Zhao-Rong Lun; Yong Wang; Lloyd H Kasper; Fangli Lu
Journal:  PLoS One       Date:  2013-10-16       Impact factor: 3.240

10.  Characteristics of Infection Immunity Regulated by Toxoplasma gondii to Maintain Chronic Infection in the Brain.

Authors:  Young Sang Hwang; Ji-Hun Shin; Jung-Pyo Yang; Bong-Kwang Jung; Sang Hyung Lee; Eun-Hee Shin
Journal:  Front Immunol       Date:  2018-02-05       Impact factor: 7.561
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