| Literature DB >> 14638512 |
Fátima Lasala1, Eva Arce, Joaquín R Otero, Javier Rojo, Rafael Delgado.
Abstract
We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.Entities:
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Year: 2003 PMID: 14638512 PMCID: PMC296220 DOI: 10.1128/AAC.47.12.3970-3972.2003
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191