Literature DB >> 14638512

Mannosyl glycodendritic structure inhibits DC-SIGN-mediated Ebola virus infection in cis and in trans.

Fátima Lasala1, Eva Arce, Joaquín R Otero, Javier Rojo, Rafael Delgado.   

Abstract

We have designed a glycodendritic structure, BH30sucMan, that blocks the interaction between dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) and Ebola virus (EBOV) envelope. BH30sucMan inhibits DC-SIGN-mediated EBOV infection at nanomolar concentrations. BH30sucMan may counteract important steps of the infective process of EBOV and, potentially, of microorganisms shown to exploit DC-SIGN for cell entry and infection.

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Year:  2003        PMID: 14638512      PMCID: PMC296220          DOI: 10.1128/AAC.47.12.3970-3972.2003

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


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