| Literature DB >> 14636724 |
Ji Hoon Jeong1, Sung Wan Kim, Tae Gwan Park.
Abstract
The conjugate of antisense c-raf oligonucleotide (ODN) and poly(ethylene glycol) (PEG) was synthesized for intracellular ODN delivery. When combined with polyethylenimine (PEI), the ODN-PEG conjugate self-associated to form polyelectrolyte complex micelles in aqueous solution. The effective hydrodynamic diameter of the micelles was ca. 70 nm with a narrow size distribution. Flow cytometry analysis indicated that the cellular uptake of the micelles by A2780 cells was much higher than that of ODN alone. The micelles also showed a superior antiproliferative activity against ovarian cancer cells in vitro and in vivo.Entities:
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Year: 2003 PMID： 14636724 DOI： 10.1016/j.jconrel.2003.07.002
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776