| Literature DB >> 14636721 |
C Vauthier1, C Dubernet, C Chauvierre, I Brigger, P Couvreur.
Abstract
Simultaneous cellular resistance to multiple lipophilic drugs represents a major problem in cancer chemotherapy. This drug resistance may appear clinically either as a lack of tumor size reduction or as the occurrence of clinical relapse after an initial positive response to antitumor treatment. The resistance mechanism can have different origins either directly linked to specific mechanisms developed by the tumor tissue or connected to the more general problem of distribution of a drug towards its targeted tissue. The purpose of this paper is to summarize the results of the use of poly(alkyl cyanoacrylate) nanoparticles to overcome multidrug resistance (MDR) phenomena at both the cellular and the non-cellular level.Entities:
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Year: 2003 PMID： 14636721 DOI： 10.1016/j.jconrel.2003.08.005
Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776