Literature DB >> 14636553

HtrA2/Omi, a sheep in wolf's clothing.

David L Vaux1, John Silke.   

Abstract

Mammalian mitochondrial HtrA2/Omi was originally described as an apoptosis inducer, but rather than having extra cells, mice with mutant HtrA2/Omi suffer from a neurodegenerative disease due to progressive mitochondrial damage. This suggests that instead of promoting cell death by antagonizing inhibitor of apoptosis (IAP) proteins, the primary function of HtrA2/Omi is to handle misfolded proteins in the mitochondria.

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Year:  2003        PMID： 14636553     DOI： 10.1016/s0092-8674(03)00851-1

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  10 in total

1.  Mature DIABLO/Smac is produced by the IMP protease complex on the mitochondrial inner membrane.

Authors:  Lena Burri; Yvan Strahm; Christine J Hawkins; Ian E Gentle; Michelle A Puryer; Anne Verhagen; Bernard Callus; David Vaux; Trevor Lithgow
Journal:  Mol Biol Cell       Date:  2005-04-06       Impact factor: 4.138

2.  Unique anti-apoptotic activity of EAAC1 in injured motor neurons.

Authors:  Sumiko Kiryu-Seo; Kazushige Gamo; Taro Tachibana; Kohichi Tanaka; Hiroshi Kiyama
Journal:  EMBO J       Date:  2006-07-13       Impact factor: 11.598

3.  Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

Authors:  L Miguel Martins; Alastair Morrison; Kristina Klupsch; Valentina Fedele; Nicoleta Moisoi; Peter Teismann; Alejandro Abuin; Evelyn Grau; Martin Geppert; George P Livi; Caretha L Creasy; Alison Martin; Iain Hargreaves; Simon J Heales; Hitoshi Okada; Sebastian Brandner; Jörg B Schulz; Tak Mak; Julian Downward
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

Review 4.  No death without life: vital functions of apoptotic effectors.

Authors:  L Galluzzi; N Joza; E Tasdemir; M C Maiuri; M Hengartner; J M Abrams; N Tavernarakis; J Penninger; F Madeo; G Kroemer
Journal:  Cell Death Differ       Date:  2008-02-29       Impact factor: 15.828

5.  Stress Conditions Increase Vimentin Cleavage by Omi/HtrA2 Protease in Human Primary Neurons and Differentiated Neuroblastoma Cells.

Authors:  Bérangère Lucotte; Mehdi Tajhizi; Dareen Alkhatib; Eva-Britt Samuelsson; Birgitta Wiehager; Sophia Schedin-Weiss; Erik Sundström; Bengt Winblad; Lars O Tjernberg; Homira Behbahani
Journal:  Mol Neurobiol       Date:  2014-10-08       Impact factor: 5.590

6.  The role of apoptosis in the pathology of pancreatic cancer.

Authors:  Nicole Samm; Kristin Werner; Felix Rückert; Hans Detlev Saeger; Robert Grützmann; Christian Pilarsky
Journal:  Cancers (Basel)       Date:  2010-12-23       Impact factor: 6.639

7.  Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.

Authors:  L S Tain; R B Chowdhury; R N Tao; H Plun-Favreau; N Moisoi; L M Martins; J Downward; A J Whitworth; N Tapon
Journal:  Cell Death Differ       Date:  2009-03-13       Impact factor: 15.828

8.  HtrA2/Omi terminates cytomegalovirus infection and is controlled by the viral mitochondrial inhibitor of apoptosis (vMIA).

Authors:  A Louise McCormick; Linda Roback; Edward S Mocarski
Journal:  PLoS Pathog       Date:  2008-05-09       Impact factor: 6.823

Review 9.  Pathogenesis of colorectal carcinoma and therapeutic implications: the roles of the ubiquitin-proteasome system and Cox-2.

Authors:  Ioannis A Voutsadakis
Journal:  J Cell Mol Med       Date:  2007 Mar-Apr       Impact factor: 5.310

10.  Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.

Authors:  Taher Darreh-Shori; Sareh Rezaeianyazdi; Erica Lana; Sumonto Mitra; Anna Gellerbring; Azadeh Karami; Nenad Bogdanovic; Christina Unger Lithner; Bengt Winblad; Homira Behbahani
Journal:  Mol Neurobiol       Date:  2018-10-25       Impact factor: 5.590
  10 in total

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