PURPOSE: We previously revealed an interictal increase in intensity of EEG rhythms during quiescent mental activity in the 30- to 100-Hz frequency (gamma) range in primary generalized epilepsy (PGE). We have evidence that there is induction of gamma EEG in normal subjects in response to controlled mental activity. Here we test whether mental tasks further augment interictal gamma oscillations in people with PGE. METHODS: We recorded interictal EEG from patients with PGE and partial epilepsy and compared EEG power spectral responses (increases over resting) during mental tasks. RESULTS: In partial epilepsy, mental tasks (except for alternating checkerboard visual stimulation) induced 1.5- to 2.5-fold increases in power of gamma EEG. In generalized epilepsy, generalized increases of 1.5-fold in gamma EEG were induced by only two mental tasks (reading and subtraction), and enhancement of 1- to 1.5-fold in the remaining six (checkerboard, expectancy, music, learning, recalling, and a video). CONCLUSIONS: Gamma EEG is less responsive to mental activation in PGE than in partial epilepsy, confirming an abnormality in gamma mechanisms in PGE. Our findings also provide a possible mechanistic link between mental activity and seizures in reading- and arithmetic-induced seizures.
PURPOSE: We previously revealed an interictal increase in intensity of EEG rhythms during quiescent mental activity in the 30- to 100-Hz frequency (gamma) range in primary generalized epilepsy (PGE). We have evidence that there is induction of gamma EEG in normal subjects in response to controlled mental activity. Here we test whether mental tasks further augment interictal gamma oscillations in people with PGE. METHODS: We recorded interictal EEG from patients with PGE and partial epilepsy and compared EEG power spectral responses (increases over resting) during mental tasks. RESULTS: In partial epilepsy, mental tasks (except for alternating checkerboard visual stimulation) induced 1.5- to 2.5-fold increases in power of gamma EEG. In generalized epilepsy, generalized increases of 1.5-fold in gamma EEG were induced by only two mental tasks (reading and subtraction), and enhancement of 1- to 1.5-fold in the remaining six (checkerboard, expectancy, music, learning, recalling, and a video). CONCLUSIONS: Gamma EEG is less responsive to mental activation in PGE than in partial epilepsy, confirming an abnormality in gamma mechanisms in PGE. Our findings also provide a possible mechanistic link between mental activity and seizures in reading- and arithmetic-induced seizures.
Authors: Kenneth J Pope; Trent W Lewis; Sean P Fitzgibbon; Azin S Janani; Tyler S Grummett; Patricia A H Williams; Malcolm Battersby; Tarun Bastiampillai; Emma M Whitham; John O Willoughby Journal: Brain Behav Date: 2022-08-02 Impact factor: 3.405