Literature DB >> 1463580

The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation.

M Harnett1, K Rigley.   

Abstract

The relative roles of G-proteins and protein tyrosine kinases (PTKs) in the regulation of antigen receptor-mediated signalling in B and T cells is controversial. As they, and the biochemical events they control, are potential targets for intervention in various immune dysfunctions, the resolution of the controversy is of great interest. Here, Margaret Harnett and Kevin Rigley provide a timely assessment of current understanding, and propose a model for the interaction of G-proteins and PTKs in antigen receptor-mediated signalling.

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Year:  1992        PMID： 1463580     DOI： 10.1016/0167-5699(92)90022-Y

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  9 in total

1.  The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes.

Authors:  K R Solomon; C E Rudd; R W Finberg
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-11       Impact factor: 11.205

2.  MAPkinase: a second site of G-protein regulation of B-cell activation via the antigen receptors.

Authors:  M R Deehan; G G Klaus; M J Holman; W Harnett; M M Harnett
Journal:  Immunology       Date:  1998-10       Impact factor: 7.397

Review 3.  The selectins: insights into selectin-induced intracellular signaling in leukocytes.

Authors:  E Crockett-Torabi; J C Fantone
Journal:  Immunol Res       Date:  1995       Impact factor: 2.829

4.  Differential G-protein expression during B- and T-cell development.

Authors:  K R Grant; W Harnett; G Milligan; M M Harnett
Journal:  Immunology       Date:  1997-04       Impact factor: 7.397

5.  The role of tyrosine phosphorylation in lipopolysaccharide- and zymosan-induced procoagulant activity and tissue factor expression in macrophages.

Authors:  A P Dackiw; S Grinstein; G F Brisseau; I D McGilvray; A B Nathens; J A McGuire; R Romanek; P Y Cheung; O D Rotstein
Journal:  Infect Immun       Date:  1997-06       Impact factor: 3.441

6.  T-lymphocyte activation and the cellular form of the prion protein.

Authors:  N A Mabbott; K L Brown; J Manson; M E Bruce
Journal:  Immunology       Date:  1997-10       Impact factor: 7.397

7.  Protein-tyrosine phosphorylation regulates apoptosis in human eosinophils and neutrophils.

Authors:  S Yousefi; D R Green; K Blaser; H U Simon
Journal:  Proc Natl Acad Sci U S A       Date:  1994-11-08       Impact factor: 11.205

8.  The role of protease-activated receptor 1 signaling in CD8 T cell effector functions.

Authors:  Hui Chen; Mindy Smith; Jasmin Herz; Tong Li; Rebecca Hasley; Cecile Le Saout; Ziang Zhu; Jie Cheng; Andres Gronda; José A Martina; Pablo M Irusta; Tatiana Karpova; Dorian B McGavern; Marta Catalfamo
Journal:  iScience       Date:  2021-10-30

9.  Investigation of intracellular signals generated by gamma-interferon and IL-4 leading to the induction of class II antigen expression.

Authors:  S Vassiliadis; N Kyrpides; D Stravopodis; M Grigoriou; I Athanassakis; J Papamatheakis
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711
  9 in total

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