Manuel González-Ortiz1, Esperanza Martínez-Abundis. 1. Medical Research Unit in Clinical Epidemiology, West National Medical Center, Mexican Institute of Social Security, Guadalajara, Mexico. uiec@prodigy.net.mx
Abstract
BACKGROUND: The aim of this study was to correlate several formulas to assess insulin action in the fasting state with the hyperglycemic-hyperinsulinemic clamp method in healthy individuals. METHODS: A cross-sectional study was carried out in 33 healthy, non-obese volunteers. A hyperglycemic-hyperinsulinemic clamp technique was performed and the following formulas to assess insulin action in the fasting state were calculated: reciprocal insulin, glucose to insulin ratio, homeostasis model analysis, Raynaud index, Belfiore index, reciprocal of fasting insulin resistance index and quantitative insulin sensitivity check index. Pearson correlation was used to correlate the above mentioned formulas with the clamp method. RESULTS: There were significant correlations between results of the several formulas and those obtained with the clamp technique. The reciprocal of insulin index had better correlation with the clamp method. CONCLUSIONS: All formulas evaluated to assess insulin action in the fasting state had a significant correlation with the hyperglycemic clamp technique.
BACKGROUND: The aim of this study was to correlate several formulas to assess insulin action in the fasting state with the hyperglycemic-hyperinsulinemic clamp method in healthy individuals. METHODS: A cross-sectional study was carried out in 33 healthy, non-obese volunteers. A hyperglycemic-hyperinsulinemic clamp technique was performed and the following formulas to assess insulin action in the fasting state were calculated: reciprocal insulin, glucose to insulin ratio, homeostasis model analysis, Raynaud index, Belfiore index, reciprocal of fasting insulin resistance index and quantitative insulin sensitivity check index. Pearson correlation was used to correlate the above mentioned formulas with the clamp method. RESULTS: There were significant correlations between results of the several formulas and those obtained with the clamp technique. The reciprocal of insulin index had better correlation with the clamp method. CONCLUSIONS: All formulas evaluated to assess insulin action in the fasting state had a significant correlation with the hyperglycemic clamp technique.
Authors: Manuel González-Ortiz; Esperanza Martínez-Abundis; José A Robles-Cervantes; Maria G Ramos-Zavala; Carmelita Barrera-Durán; Jorge González-Canudas Journal: Diabetes Technol Ther Date: 2012-09-13 Impact factor: 6.118
Authors: J Holmkvist; D Tojjar; P Almgren; V Lyssenko; C M Lindgren; B Isomaa; T Tuomi; G Berglund; E Renström; L Groop Journal: Diabetologia Date: 2007-10-13 Impact factor: 10.122
Authors: Maria G Ramos-Zavala; Manuel González-Ortiz; Esperanza Martínez-Abundis; José A Robles-Cervantes; Roberto González-López; Nestor J Santiago-Hernández Journal: Diabetes Care Date: 2011-05-24 Impact factor: 19.112
Authors: María Claudia Espinel-Bermúdez; José Antonio Robles-Cervantes; Liliana del Sagrario Villarreal-Hernández; Juan Pablo Villaseñor-Romero; Sandra Ofelia Hernández-González; Manuel González-Ortiz; Esperanza Martínez-Abundis; Karina Griselda Pérez-Rubio Journal: J Investig Med Date: 2015-02 Impact factor: 2.895