Jack D Sobel1, Walter Chaim, Viji Nagappan, Deborah Leaman. 1. Division of Infectious Diseases, Wayne State University School of Medicine, Harper Hospital, 3990 John R, Detroit, MI 48201, USA. jsobel@intmed.wayne.edu
Abstract
OBJECTIVE: The purpose of this study was to review the treatment outcome and safety of topical therapy with boric acid and flucytosine in women with Candida glabrata vaginitis. STUDY DESIGN: This was a retrospective review of case records of 141 women with positive vaginal cultures of C glabrata at two sites, Wayne State University School of Medicine and Ben Gurion University. RESULTS: The boric acid regimen, 600 mg daily for 2 to 3 weeks, achieved clinical and mycologic success in 47 of 73 symptomatic women (64%) in Detroit and 27 of 38 symptomatic women (71%) in Beer Sheba. No advantage was observed in extending therapy for 14 to 21 days. Topical flucytosine cream administered nightly for 14 days was associated with a successful outcome in 27 of 30 of women (90%) whose condition had failed to respond to boric acid and azole therapy. Local side effects were uncommon with both regimens. CONCLUSIONS: Topical boric acid and flucytosine are useful additions to therapy for women with azole-refractory C glabrata vaginitis.
OBJECTIVE: The purpose of this study was to review the treatment outcome and safety of topical therapy with boric acid and flucytosine in women with Candida glabrata vaginitis. STUDY DESIGN: This was a retrospective review of case records of 141 women with positive vaginal cultures of C glabrata at two sites, Wayne State University School of Medicine and Ben Gurion University. RESULTS: The boric acid regimen, 600 mg daily for 2 to 3 weeks, achieved clinical and mycologic success in 47 of 73 symptomatic women (64%) in Detroit and 27 of 38 symptomatic women (71%) in Beer Sheba. No advantage was observed in extending therapy for 14 to 21 days. Topical flucytosine cream administered nightly for 14 days was associated with a successful outcome in 27 of 30 of women (90%) whose condition had failed to respond to boric acid and azole therapy. Local side effects were uncommon with both regimens. CONCLUSIONS: Topical boric acid and flucytosine are useful additions to therapy for women with azole-refractory C glabrata vaginitis.
Authors: Claire S Danby; Dina Boikov; Rina Rautemaa-Richardson; Jack D Sobel Journal: Antimicrob Agents Chemother Date: 2012-01-09 Impact factor: 5.191
Authors: Linn Woelber; Katharina Prieske; Werner Mendling; Barbara Schmalfeldt; Hans-Jürgen Tietz; Anna Jaeger Journal: Dtsch Arztebl Int Date: 2020-02-21 Impact factor: 5.594