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Literature DB >> 146342

[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)].

Abstract

The carcinogenic p-Dimethylaminoazobenzene and the non-carcinogenic p-aminoazobenzene were radioactive labelled and applicated to Whistar rats intraperitoneally. A very significant difference in binding tendencies for the two compounds and their metabolites was observed in rat liver tissues, rat liver nuclei and rat liver chromatin. Above all a specific binding affinity of the carcinogen to nuclear non-histone protein was found.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1978 PMID： 146342 DOI： 10.1007/bf00305972

Source DB: PubMed Journal: Z Krebsforsch Klin Onkol Cancer Res Clin Oncol ISSN： 0084-5353

18 in total

1. Role of non-histone components in determining organ specificity of rabbit chromatins.

Authors: R S. Gilmour; J Paul
Journal: FEBS Lett Date: 1970-08-17 Impact factor: 4.124

2. Reconstitution of bacterial DNA-dependent RNA-polymerase from isolated subunits as a tool for the elucidation of the role of the subunits in transcription.

Authors: A Heil; W Zillig
Journal: FEBS Lett Date: 1970-12 Impact factor: 4.124

3. [On the mechanism of action of inducer substances. I. Fractionation of calf thymus chromatin and characterization of a specific DNA-protein complex].

Authors: J Sonnenbichler; G W Bornkamm
Journal: Hoppe Seylers Z Physiol Chem Date: 1967-12

Review 4. Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

Authors: J A Miller
Journal: Cancer Res Date: 1970-03 Impact factor: 12.701

5. Azoproteins of liver nuclei isolated in an aqueous or nonaqueous medium from rats fed an azocarcinogen.

Authors: B Bakay; S Sorof; G Siebert
Journal: Cancer Res Date: 1969-01 Impact factor: 12.701

6. The so-called non-histones from acid-treated calf thymus chromatin.

Authors: J Sonnenbichler; P Nobis
Journal: Eur J Biochem Date: 1970-09

7. Binding of metabolites of dietary 4-dimethyl-aminoazobenzene and 2-methyl-4-dimethylamino-azobenzene to rat liver DNA and protein of subcellular fractions.

Authors: J Chauveau; M Meunier; A Benoit
Journal: Int J Cancer Date: 1974-01-15 Impact factor: 7.396

[Interaction of p-Dimethylaminoazobenzene with rat liver-chromatin and non-histones (author's transl)].

1. Role of non-histone components in determining organ specificity of rabbit chromatins.

2. Reconstitution of bacterial DNA-dependent RNA-polymerase from isolated subunits as a tool for the elucidation of the role of the subunits in transcription.

3. [On the mechanism of action of inducer substances. I. Fractionation of calf thymus chromatin and characterization of a specific DNA-protein complex].

Review 4. Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

5. Azoproteins of liver nuclei isolated in an aqueous or nonaqueous medium from rats fed an azocarcinogen.

6. The so-called non-histones from acid-treated calf thymus chromatin.

7. Binding of metabolites of dietary 4-dimethyl-aminoazobenzene and 2-methyl-4-dimethylamino-azobenzene to rat liver DNA and protein of subcellular fractions.

8. The binding of metabolites of aminoazo dyes to rat liver DNA in vivo.

9. Sulfhydryl groups and estradiol-receptor interaction.

10. The interaction of tritiated rho-dimethylaminoazobenzene with rat liver nuclear proteins.

1. Covalent binding of drug metabolites to DNA--a tool of predictive value?