Literature DB >> 1463392

Reproductive toxicity and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects of single doses on the testis of male rats.

I Chahoud1, J Hartmann, G M Rune, D Neubert.   

Abstract

The effects of a single dose of TCDD on the testis were studied in rats. The animals were treated (subcutaneously) once with TCDD doses of 0, 0.5, 1.0, 3.0, 5.0 micrograms/kg body weight. Doses of 3.0 or 5.0 micrograms TCDD/kg reduced the number of spermatids/testis significantly (60% of the controls). Electron microscopic inspection revealed that both doses led to a dissolution on the germinal epithelium. Altered germ cells at all developmental stages occurred in all testes evaluated. Doses of 0.5 or 1.0 micrograms TCDD/kg did not induce any effects in the testis; therefore, under these experimental conditions of single exposure to rats the dose of 1.0 micrograms TCDD/kg can be considered as NOAEL.

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Year:  1992        PMID： 1463392     DOI： 10.1007/bf01973387

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  17 in total

1.  Morphological and histochemical pattern of response in rat testes after administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

Authors:  G M Rune; P de Souza; R Krowke; H J Merker; D Neubert
Journal:  Histol Histopathol       Date:  1991-10       Impact factor: 2.303

2.  Obstruction of the tubuli recti and ductuli efferentes by dilated veins in the testes of men with varicocele and its possible role in causing atrophy of the seminiferous tubules.

Authors:  M Nistal; R Paniagua; J Regadera; L Santamaria
Journal:  Int J Androl       Date:  1984-08

Review 3.  Physiological significance of fluid secretion in the testis and blood-testis barrier.

Authors:  G M Waites; R T Gladwell
Journal:  Physiol Rev       Date:  1982-04       Impact factor: 37.312

4.  The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs.

Authors:  E E McConnell; J A Moore; J K Haseman; M W Harris
Journal:  Toxicol Appl Pharmacol       Date:  1978-05       Impact factor: 4.219

5.  Light and electron microscopic observations in Macaca mulatta monkeys fed toxic fat.

Authors:  J R Allen; L A Carstens
Journal:  Am J Vet Res       Date:  1967-09       Impact factor: 1.156

6.  Transfer of various polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDDs and PCDFs) via placenta and through milk in a marmoset monkey.

Authors:  H Hagenmaier; T Wiesmüller; G Golor; R Krowke; H Helge; D Neubert
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

7.  2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD): results of a 13-week oral toxicity study in rats.

Authors:  R J Kociba; P A Keeler; C N Park; P J Gehring
Journal:  Toxicol Appl Pharmacol       Date:  1976-03       Impact factor: 4.219

8.  Male fertility, sister chromatid exchange, and germ cell toxicity following exposure to mixtures of chlorinated phenoxy acids containing 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  J C Lamb; T A Marks; B C Gladen; J W Allen; J A Moore
Journal:  J Toxicol Environ Health       Date:  1981 Nov-Dec

9.  Health status of Vietnam veterans. II. Physical Health. The Centers for Disease Control Vietnam Experience Study.

Authors: 
Journal:  JAMA       Date:  1988-05-13       Impact factor: 56.272

10.  The ultrastructural basis of capillary permeability studied with peroxidase as a tracer.

Authors:  M J Karnovsky
Journal:  J Cell Biol       Date:  1967-10       Impact factor: 10.539
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  7 in total

Review 1.  Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses.

Authors:  Laura N Vandenberg; Theo Colborn; Tyrone B Hayes; Jerrold J Heindel; David R Jacobs; Duk-Hee Lee; Toshi Shioda; Ana M Soto; Frederick S vom Saal; Wade V Welshons; R Thomas Zoeller; John Peterson Myers
Journal:  Endocr Rev       Date:  2012-03-14       Impact factor: 19.871

2.  Ancestral TCDD Exposure Induces Multigenerational Histologic and Transcriptomic Alterations in Gonads of Male Zebrafish.

Authors:  Danielle N Meyer; Bridget B Baker; Tracie R Baker
Journal:  Toxicol Sci       Date:  2018-08-01       Impact factor: 4.849

Review 3.  Dioxin-induced changes in epididymal sperm count and spermatogenesis.

Authors:  Warren G Foster; Serena Maharaj-Briceño; Daniel G Cyr
Journal:  Environ Health Perspect       Date:  2010-04       Impact factor: 9.031

4.  Peri- and postnatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: effects on physiological development, reflexes, locomotor activity and learning behaviour in Wistar rats.

Authors:  R Thiel; E Koch; B Ulbrich; I Chahoud
Journal:  Arch Toxicol       Date:  1994       Impact factor: 5.153

5.  Histological and Transcriptomic Changes in Male Zebrafish Testes Due to Early Life Exposure to Low Level 2,3,7,8-Tetrachlorodibenzo-p-Dioxin.

Authors:  Bridget B Baker; Jeremiah S Yee; Danielle N Meyer; Doris Yang; Tracie R Baker
Journal:  Zebrafish       Date:  2016-10       Impact factor: 1.985

6.  Animal Toxicology Studies on the Male Reproductive Effects of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin: Data Analysis and Health Effects Evaluation.

Authors:  Tongtong Zhang; Xiang Zhou; Xiaohan Ren; Xu Zhang; Jiajin Wu; Shangqian Wang; Zengjun Wang
Journal:  Front Endocrinol (Lausanne)       Date:  2021-11-03       Impact factor: 5.555

7.  Semen quality in relation to xenohormone and dioxin-like serum activity among Inuits and three European populations.

Authors:  Gunnar Toft; Manhai Long; Tanja Krüger; Philip S Hjelmborg; Jens Peter Bonde; Anna Rignell-Hydbom; Ewa Tyrkiel; Lars Hagmar; Aleksander Giwercman; Marcello Spanó; Davide Bizzaro; Henning S Pedersen; Vladymir Lesovoy; Jan K Ludwicki; Eva C Bonefeld-Jørgensen
Journal:  Environ Health Perspect       Date:  2007-12       Impact factor: 9.031
  7 in total

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