Literature DB >> 14631549

Tumor microenvironment and hemorheological abnormalities.

Gianfranco Baronzio1, Isabel Freitas, Hau C Kwaan.   

Abstract

This article reviews the various mechanisms in a malignant tumor that lead to hypoxia, production of tumor interstitial fluid, and rheological changes in its microenvironment. In addition, the associated procoagulant effects are described. The latter phenomenon is the result of complex and dynamic interplay among tumor cells, endothelial cells, circulating blood cells, and angiogenic, clotting, and hemorheological factors. The implications of these abnormalities on therapeutic approach are discussed.

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Mesh：

Year:  2003        PMID： 14631549     DOI： 10.1055/s-2003-44557

Source DB:  PubMed          Journal:  Semin Thromb Hemost        ISSN： 0094-6176            Impact factor:   4.180


  7 in total

1.  Haemostatic responsiveness and release of biological response modifiers following cryopreservation of platelets treated with amotosalen and ultraviolet A light.

Authors:  Nahreen Tynngård; Agneta Wikman; Michael Uhlin; Per Sandgren
Journal:  Blood Transfus       Date:  2019-07-04       Impact factor: 3.443

2.  Novel In Situ Collection of Tumor Interstitial Fluid from a Head and Neck Squamous Carcinoma Reveals a Unique Proteome with Diagnostic Potential.

Authors:  Matthew D Stone; Rick M Odland; Thomas McGowan; Getiria Onsongo; Chaunning Tang; Nelson L Rhodus; Pratik Jagtap; Sricharan Bandhakavi; Timothy J Griffin
Journal:  Clin Proteomics       Date:  2010-07-25       Impact factor: 3.988

Review 3.  Overview of Methods for Overcoming Hindrance to Drug Delivery to Tumors, with Special Attention to Tumor Interstitial Fluid.

Authors:  Gianfranco Baronzio; Gurdev Parmar; Miriam Baronzio
Journal:  Front Oncol       Date:  2015-07-23       Impact factor: 6.244

4.  High EMT Signature Score of Invasive Non-Small Cell Lung Cancer (NSCLC) Cells Correlates with NFκB Driven Colony-Stimulating Factor 2 (CSF2/GM-CSF) Secretion by Neighboring Stromal Fibroblasts.

Authors:  Albin Rudisch; Matthew Richard Dewhurst; Luminita Gabriela Horga; Nina Kramer; Nathalie Harrer; Meng Dong; Heiko van der Kuip; Andreas Wernitznig; Andreas Bernthaler; Helmut Dolznig; Wolfgang Sommergruber
Journal:  PLoS One       Date:  2015-04-28       Impact factor: 3.240

5.  Proteomic analysis of non-small cell lung cancer tissue interstitial fluids.

Authors:  Shaomin Li; Rui Wang; Mingxin Zhang; Lina Wang; Shaoli Cheng
Journal:  World J Surg Oncol       Date:  2013-08-05       Impact factor: 2.754

Review 6.  The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance.

Authors:  Gvantsa Kharaishvili; Dana Simkova; Katerina Bouchalova; Mariam Gachechiladze; Nato Narsia; Jan Bouchal
Journal:  Cancer Cell Int       Date:  2014-05-16       Impact factor: 5.722

Review 7.  Pathophysiological Basis for the Formation of the Tumor Microenvironment.

Authors:  Michael R Horsman; Peter Vaupel
Journal:  Front Oncol       Date:  2016-04-12       Impact factor: 6.244
  7 in total

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