Literature DB >> 14631505

Possible prediction of the efficiency of chemotherapy in patients with lymphoproliferative diseases based on MDR1 gene G2677T and C3435T polymorphisms.

O B Goreva1, A Yu Grishanova, O V Mukhin, N P Domnikova, V V Lyakhovich.   

Abstract

Study of polymorphism in MDR1 gene exons 21 and 26 revealed that T2677T and T3435T alleles are not a factor predisposing to lymphoproliferative diseases, but they determine the efficiency chemotherapy. Individuals with T2677T and T3435T haplotypes are at highest risk of drug resistance. Association between genotypes G2677T and C3435T was detected in normal subjects and in patients with lymphoproliferative diseases.

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Year:  2003        PMID： 14631505     DOI： 10.1023/a:1026331326648

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  9 in total

1.  Roles of ABCB1 gene polymorphisms and haplotype in susceptibility to breast carcinoma risk and clinical outcomes.

Authors:  Huizhe Wu; Hui Kang; Yong Liu; Weiwei Tong; Duo Liu; Xiuli Yang; Minqiong Lian; Weifan Yao; Haishan Zhao; Desheng Huang; Xianzheng Sha; Enhua Wang; Minjie Wei
Journal:  J Cancer Res Clin Oncol       Date:  2012-04-19       Impact factor: 4.553

2.  Different frequencies and effects of ABCB1 T3435C polymorphism on clinical and laboratory features of B cell chronic lymphocytic leukemia in Kurdish patients.

Authors:  Farzad Maroofi; Sabrieh Amini; Daem Roshani; Bayazid Ghaderi; Mohammad Abdi
Journal:  Tumour Biol       Date:  2015-01-15

Review 3.  Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer.

Authors:  Tessa M Bosch; Irma Meijerman; Jos H Beijnen; Jan H M Schellens
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

4.  Ethnicity-related polymorphisms and haplotypes in the human ABCB1 gene.

Authors:  Chava Kimchi-Sarfaty; Andrew H Marple; Shiri Shinar; Avraham M Kimchi; David Scavo; M Isabella Roma; In-Wha Kim; Adam Jones; Mili Arora; John Gribar; David Gurwitz; Michael M Gottesman
Journal:  Pharmacogenomics       Date:  2007-01       Impact factor: 2.533

5.  MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an impact on susceptibility and prognosis.

Authors:  G Penna; A Allegra; A Alonci; M Aguennouz; A Garufi; A Cannavò; D Gerace; A Alibrandi; C Musolino
Journal:  Med Oncol       Date:  2010-05-22       Impact factor: 3.064

6.  MDR-1 gene polymorphisms G2677T and C3435T in a case of Hodgkin's variant of Richter's syndrome.

Authors:  Giuseppa Penna; Alessandro Allegra; Andrea Alonci; Mohamed Aguennouz; Antonino Cannavò; Sabina Russo; Angela Granata; Caterina Musolino
Journal:  Oncol Lett       Date:  2011-01-20       Impact factor: 2.967

Review 7.  Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima.

Authors:  Chung-Jung Tsai; Zuben E Sauna; Chava Kimchi-Sarfaty; Suresh V Ambudkar; Michael M Gottesman; Ruth Nussinov
Journal:  J Mol Biol       Date:  2008-08-12       Impact factor: 5.469

8.  Multi-drug resistance 1 genetic polymorphism and prediction of chemotherapy response in Hodgkin's Lymphoma.

Authors:  Nizar M Mhaidat; Osama Y Alshogran; Omar F Khabour; Karem H Alzoubi; Ismail I Matalka; William J Haddadin; Ibraheem O Mahasneh; Ahmad N Aldaher
Journal:  J Exp Clin Cancer Res       Date:  2011-07-16

Review 9.  Towards Comprehension of the ABCB1/P-Glycoprotein Role in Chronic Myeloid Leukemia.

Authors:  Raquel C Maia; Flavia C Vasconcelos; Paloma S Souza; Vivian M Rumjanek
Journal:  Molecules       Date:  2018-01-07       Impact factor: 4.411
  9 in total

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