Literature DB >> 14631489

Effect of antioxidant probucol on cell-mediated LDL oxidation in vitro and in vivo.

M V Bilenko1, A V Khil'chenko, G G Konovalova, V Z Lankin.   

Abstract

We studied the effect of phenol antioxidant probucol on free radical oxidation of LDL isolated from blood plasma of healthy donors. Oxidation was induced by co-incubation of LDL with cultured peripheral blood monocyte-macrophages and human umbilical vein endothelial cells under conditions of ischemia-reperfusion. In addition, the effect of probucol therapy on oxidability of plasma LDL in CHD patients was examined. Probucol (0.1-10 microM) efficiently protected LDL from free radical oxidation in vitro and in vivo.

Entities:  

Mesh：

Substances：

Year:  2003        PMID： 14631489     DOI： 10.1023/a:1026398319379

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  3 in total

1.  Macrophages actively accumulate malonyldialdehyde-modified but not enzymatically oxidized low density lipoprotein.

Authors:  V Z Lankin; A K Tikhaze; E M Kumskova
Journal:  Mol Cell Biochem       Date:  2012-02-04       Impact factor: 3.396

2.  Synergistic efficacy of concurrent treatment with cilostazol and probucol on the suppression of reactive oxygen species and inflammatory markers in cultured human coronary artery endothelial cells.

Authors:  So Youn Park; Jeong Hyun Lee; Hwa Kyoung Shin; Chi Dae Kim; Won Suk Lee; Byung Yong Rhim; Yung Woo Shin; Ki Whan Hong
Journal:  Korean J Physiol Pharmacol       Date:  2008-08-31       Impact factor: 2.016

3.  Succinobucol's new coat--conjugation with steroids to alter its drug effect and bioavailability.

Authors:  Ondřej Jurček; Satu Ikonen; Lucie Buřičová; Martina Wimmerová; Zdeněk Wimmer; Pavel Drašar; Jan Horníček; Adéla Galandáková; Jitka Ulrichová; Erkki T Kolehmainen
Journal:  Molecules       Date:  2011-11-10       Impact factor: 4.411
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.