| Literature DB >> 14630351 |
Mitsuhito Mase1, Kazuo Yamada, Naoki Shimazu, Kosuke Seiki, Hiroshi Oda, Hiroya Nakau, Takashi Inui, Weidong Li, Naomi Eguchi, Yoshihiro Urade.
Abstract
Lipocalin-type prostaglandin D synthase (PGDS) is considered to be mainly produced in the leptomeninges and secreted into cerebrospinal fluid (CSF). We found PGDS levels in CSF of patients with normal pressure hydrocephalus (NPH) (8.99+/-2.59 microg/ml, mean+/-S.D., n=14) to be significantly lower than levels in a control (15.29+/-5.17, n=14, P<0.0001) and other dementia group (19.14+/-4.34, n=7, P=0.0003). Thus, PGDS level in CSF is a useful marker for the differential diagnosis of NPH from other diseases with dementia.Entities:
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Year: 2003 PMID: 14630351 DOI: 10.1016/j.neures.2003.08.009
Source DB: PubMed Journal: Neurosci Res ISSN: 0168-0102 Impact factor: 3.304