| Literature DB >> 14630237 |
Nadine Azas1, Pascal Rathelot, Serge Djekou, Florence Delmas, A Gellis, Carole Di Giorgio, Patrice Vanelle, Pierre Timon-David.
Abstract
4-[2-(1,3-Dimethyl-5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)vinyl]benzaldehyde was synthesized in four steps from 6-methyl-1H,3H-pyrimidine-2,4-dione. This aldehyde was functionalized by various substituted anilines or substituted benzylamines. Antiparasitic activities of the corresponding azomethines were assessed against Plasmodium falciparum, Trichomonas vaginalis and Leishmania infantum compared to their toxicity versus human cells.Entities:
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Year: 2003 PMID： 14630237 DOI： 10.1016/j.farmac.2003.07.009
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X