| Literature DB >> 14630234 |
Ho Yoo1, Jae Yeol Lee, Jang Hyun Park, Bong Young Chung, Yong Sup Lee.
Abstract
A series of styrylbenzofuran derivatives (8a-i) as styrylquinoline isosters were efficiently prepared by Wittig reaction and evaluated for inhibitory activity against HIV-1 integrase. In this series, compounds 8g, 8h and 8i containing a free catechol ring showed moderate inhibitory activities (IC50= approximately 40 microM) against HIV-1 integrase, while less than the corresponding styrylquinoline compound (I).Entities:
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Year: 2003 PMID： 14630234 DOI： 10.1016/j.farmac.2003.08.001
Source DB: PubMed Journal: Farmaco ISSN： 0014-827X