| Literature DB >> 14630213 |
Yoshimi Takai1, Kazuya Shimizu, Toshihisa Ohtsuka.
Abstract
Cadherins are Ca(2+)-dependent intercellular adhesion molecules (CAMs) and they play key roles in the intercellular junctions of a wide variety of cells, including interneuronal synapses. Nectins are Ca(2+)-independent immunoglobulin-like CAMs and they are also involved in the organization of various types of intercellular junctions, including interneuronal synapses, either in cooperation with or independently of cadherins. Intercellular adhesion through nectins induces activation of Cdc42 and Rac small G proteins, leading to a reorganization of the actin cytoskeleton, gene expression, and cell polarization.Entities:
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Year: 2003 PMID： 14630213 DOI： 10.1016/j.conb.2003.09.003
Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627