Literature DB >> 1463009

Analysis of chromosome 21 yeast artificial chromosome (YAC) clones.

F Tassone1, S Cheng, K Gardiner.   

Abstract

Chromosome 21 contains genes relevant to several important diseases. Yeast artificial chromosome (YAC) clones, because they span > 100 kbp, will provide attractive material for initiating searches for such genes. Twenty-two YAC clones, each of which maps to a region of potential relevance either to aspects of the Down syndrome phenotype or to one of the other chromosome 21-associated genetic diseases, have been analyzed in detail. Clones total approximately 6,000 kb and derive from all parts of the long arm. Rare restriction-site maps have been constructed for each clone and have been used to determine regional variations in clonability, methylation frequency, CpG island density, and CpG island frequency versus gene density. This information will be useful for the isolation and mapping of new genes to chromosome 21 and for walking in YAC libraries.

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Year:  1992        PMID： 1463009      PMCID： PMC1682922     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  43 in total

1.  Second-generation approach to the construction of yeast artificial-chromosome libraries.

Authors:  T Imai; M V Olson
Journal:  Genomics       Date:  1990-10       Impact factor: 5.736

Review 2.  CpG-rich islands and the function of DNA methylation.

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Journal:  Nature       Date:  1986 May 15-21       Impact factor: 49.962

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Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

5.  CpG islands in vertebrate genomes.

Authors:  M Gardiner-Garden; M Frommer
Journal:  J Mol Biol       Date:  1987-07-20       Impact factor: 5.469

6.  Expression of chromosome 21 specific sequences in normal and Down's syndrome tissues.

Authors:  L Stefani; J Galt; A Palmer; N Affara; M Ferguson-Smith; N C Nevin
Journal:  Nucleic Acids Res       Date:  1988-04-11       Impact factor: 16.971

7.  Down syndrome: molecular mapping of the congenital heart disease and duodenal stenosis.

Authors:  J R Korenberg; C Bradley; C M Disteche
Journal:  Am J Hum Genet       Date:  1992-02       Impact factor: 11.025

8.  The genetic defect causing familial Alzheimer's disease maps on chromosome 21.

Authors:  P H St George-Hyslop; R E Tanzi; R J Polinsky; J L Haines; L Nee; P C Watkins; R H Myers; R G Feldman; D Pollen; D Drachman
Journal:  Science       Date:  1987-02-20       Impact factor: 47.728

9.  Physical mapping around the Alzheimer disease locus on the proximal long arm of chromosome 21.

Authors:  M J Owen; L A James; J A Hardy; R Williamson; A M Goate
Journal:  Am J Hum Genet       Date:  1990-02       Impact factor: 11.025

10.  Molecular genetic approach to the characterization of the "Down syndrome region" of chromosome 21.

Authors:  M K McCormick; A Schinzel; M B Petersen; G Stetten; D J Driscoll; E S Cantu; L Tranebjaerg; M Mikkelsen; P C Watkins; S E Antonarakis
Journal:  Genomics       Date:  1989-08       Impact factor: 5.736
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  9 in total

1.  Random-breakage mapping method applied to human DNA sequences.

Authors:  M Löbrich; B Rydberg; P K Cooper
Journal:  Nucleic Acids Res       Date:  1996-05-15       Impact factor: 16.971

2.  Gene identification and DNA sequence analysis in the GC-poor 20 megabase region of human chromosome 21.

Authors:  J Yu; S Tong; Y Shen; F T Kao
Journal:  Proc Natl Acad Sci U S A       Date:  1997-06-24       Impact factor: 11.205

Review 3.  The role of SON in splicing, development, and disease.

Authors:  Xinyi Lu; Huck-Hui Ng; Paula A Bubulya
Journal:  Wiley Interdiscip Rev RNA       Date:  2014-04-30       Impact factor: 9.957

4.  A high-resolution map of 1.6 Mb in the Down syndrome region: a new map between D21S55 and ETS2.

Authors:  P Gosset; N Crété; G Ait Ghezala; D Théophile; C Van Broeckhoven; C Vayssettes; P M Sinet; N Créau
Journal:  Mamm Genome       Date:  1995-02       Impact factor: 2.957

5.  A physical map of the human APP gene in YACs.

Authors:  K Rooke; C Talbot; L James; R Anand; J A Hardy; A M Goate
Journal:  Mamm Genome       Date:  1993-11       Impact factor: 2.957

6.  GART, SON, IFNAR, and CRF2-4 genes cluster on human chromosome 21 and mouse chromosome 16.

Authors:  S Cheng; G Lutfalla; G Uze; I M Chumakov; K Gardiner
Journal:  Mamm Genome       Date:  1993       Impact factor: 2.957

7.  YAC clones targeting gene-rich regions of human chromosome 3.

Authors:  R F Williams; Y Pekarsky; S Cheng; K Gardiner
Journal:  Mamm Genome       Date:  1994-06       Impact factor: 2.957

8.  EWS-erg and EWS-Fli1 fusion transcripts in Ewing's sarcoma and primitive neuroectodermal tumors with variant translocations.

Authors:  M Giovannini; J A Biegel; M Serra; J Y Wang; Y H Wei; L Nycum; B S Emanuel; G A Evans
Journal:  J Clin Invest       Date:  1994-08       Impact factor: 14.808

9.  A long-range physical map of human chromosome 21q22.1 band from the YAC continuum.

Authors:  T Eki; M Abe; K Furuya; I Ahmad; N Fujishima; H Kishida; A Shiratori; T Onozaki; K Yokoyama; D Le Paslier; D Cohen; F Hanaoka; Y Murakami
Journal:  Mamm Genome       Date:  1996-04       Impact factor: 2.957
  9 in total

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