M Hynes1, P Calder, G Scott. 1. Bone and Joint Research Unit, The Royal London Hospital, Whitechapel, London, UK. mchynes@hotmail.com
Abstract
HYPOTHESIS: The fall in haemoglobin following unilateral total knee arthroplasty is reduced by tranexamic acid administration. METHODS: 60 patients were studied in total, 30 received tranexamic acid 10 mg/kg on induction and a further dose shortly before the release of the tourniquet. Surgery was performed by the senior author in a standardised fashion using the Freeman Samuelson cemented total knee replacement. Haemoglobin levels were measured 2 weeks pre and 3 days post operatively. Any complications were noted. A control group was matched using the Bone and Joint Research Unit database for age, sex, disease and pre-operative haemoglobin level. This group had been monitored in the same way as the group treated with tranexamic acid. RESULTS: In the group receiving no tranexamic acid the mean fall in haemoglobin was 2.8 g/dl (95% CI of mean 2.5-3.2) and in the group treated with tranexamic acid 1.7 g/dl (95% CI of mean 1.3-2) P<0.01. There were no complications in either group. CONCLUSIONS: The administration of tranexamic acid is an effective method of reducing the haemoglobin fall following knee arthroplasty.
HYPOTHESIS: The fall in haemoglobin following unilateral total knee arthroplasty is reduced by tranexamic acid administration. METHODS: 60 patients were studied in total, 30 received tranexamic acid 10 mg/kg on induction and a further dose shortly before the release of the tourniquet. Surgery was performed by the senior author in a standardised fashion using the Freeman Samuelson cemented total knee replacement. Haemoglobin levels were measured 2 weeks pre and 3 days post operatively. Any complications were noted. A control group was matched using the Bone and Joint Research Unit database for age, sex, disease and pre-operative haemoglobin level. This group had been monitored in the same way as the group treated with tranexamic acid. RESULTS: In the group receiving no tranexamic acid the mean fall in haemoglobin was 2.8 g/dl (95% CI of mean 2.5-3.2) and in the group treated with tranexamic acid 1.7 g/dl (95% CI of mean 1.3-2) P<0.01. There were no complications in either group. CONCLUSIONS: The administration of tranexamic acid is an effective method of reducing the haemoglobin fall following knee arthroplasty.
Authors: Blake P Gillette; Lori J DeSimone; Robert T Trousdale; Mark W Pagnano; Rafael J Sierra Journal: Clin Orthop Relat Res Date: 2013-01 Impact factor: 4.176
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