OBJECTIVE: To study the changes of metalloproteinases 1, 2, 13 in granulation wound after the treatment of vacuum-assisted closure (VAC). METHODS: The chronic wounds in 5 patients were treated with VAC. The expressions of MMP-1, 2, 13 in the granulation tissues of the chronic wounds were determined and quantified using RT-PCR technique before and at 1, 4, 7 days after the treatment. RESULTS: The MMP-1, 13 mRNA showed obvious decrease, with the steepest variation of MMP-13. The MMP-2 mRNA also showed a decreased tendency, though in an undulatory fashion. CONCLUSION: VAC can promote healing of chronic wounds through depressing the expressions of MMP-1, 2, 13 mRNA and protein synthesis, depressing the degradations of collagen and gelatin.
OBJECTIVE: To study the changes of metalloproteinases 1, 2, 13 in granulation wound after the treatment of vacuum-assisted closure (VAC). METHODS: The chronic wounds in 5 patients were treated with VAC. The expressions of MMP-1, 2, 13 in the granulation tissues of the chronic wounds were determined and quantified using RT-PCR technique before and at 1, 4, 7 days after the treatment. RESULTS: The MMP-1, 13 mRNA showed obvious decrease, with the steepest variation of MMP-13. The MMP-2 mRNA also showed a decreased tendency, though in an undulatory fashion. CONCLUSION: VAC can promote healing of chronic wounds through depressing the expressions of MMP-1, 2, 13 mRNA and protein synthesis, depressing the degradations of collagen and gelatin.
Authors: Tatjana Fleck; Ronny Gustafsson; Keith Harding; Richard Ingemansson; Mitchell D Lirtzman; Herbert L Meites; Reinhard Moidl; Patricia Price; Andrew Ritchie; Jorge Salazar; Johan Sjögren; David H Song; Bauer E Sumpio; Boulos Toursarkissian; Ferdinand Waldenberger; Walter Wetzel-Roth Journal: Int Wound J Date: 2006-12 Impact factor: 3.315
Authors: Valentina Izzo; Marco Meloni; Laura Giurato; Valeria Ruotolo; Luigi Uccioli Journal: Adv Wound Care (New Rochelle) Date: 2017-01-01 Impact factor: 4.730