OBJECTIVE: To compare the efficacy and safety of naphthoquine, artemisinine and a combination of the two drugs in the treatment of faciparum malaria. METHODS: Of 230 patients, 100 patients were treated with combined regime (Co-NQ), 100 patients were treated with naphthoquine (NQ) and 30 patients were treated with artemisinine (QHS). All patients were hospitalized for 7 days and followed up for 28 days. RESULTS: The mean fever clearance time for Co-NQ, NQ, and QHS was (17.5 +/- 12.3)h, (32.7 +/- 17.7)h and (18.1 +/- 9.7)h respectively; the mean parasite clearance time was (30.0 +/- 8.8)h, (45.5 +/- 10.0)h and (29.1 +/- 6.0)h respectively; and the 28 days cure rate was 97.0%, 100.0% and 66.7% respectively. CONCLUSION: The Co-NQ possesses benefits of both naphthoquine and artemisinine, acting rapidly, with a short course of only one dose and a high cure rate. The regime is well tolerated by patients.
OBJECTIVE: To compare the efficacy and safety of naphthoquine, artemisinine and a combination of the two drugs in the treatment of faciparum malaria. METHODS: Of 230 patients, 100 patients were treated with combined regime (Co-NQ), 100 patients were treated with naphthoquine (NQ) and 30 patients were treated with artemisinine (QHS). All patients were hospitalized for 7 days and followed up for 28 days. RESULTS: The mean fever clearance time for Co-NQ, NQ, and QHS was (17.5 +/- 12.3)h, (32.7 +/- 17.7)h and (18.1 +/- 9.7)h respectively; the mean parasite clearance time was (30.0 +/- 8.8)h, (45.5 +/- 10.0)h and (29.1 +/- 6.0)h respectively; and the 28 days cure rate was 97.0%, 100.0% and 66.7% respectively. CONCLUSION: The Co-NQ possesses benefits of both naphthoquine and artemisinine, acting rapidly, with a short course of only one dose and a high cure rate. The regime is well tolerated by patients.
Authors: Nicholas J White; Tran T Duong; Chirapong Uthaisin; François Nosten; Aung P Phyo; Borimas Hanboonkunupakarn; Sasithon Pukrittayakamee; Podjanee Jittamala; Kittiphum Chuthasmit; Ming S Cheung; Yiyan Feng; Ruobing Li; Baldur Magnusson; Marc Sultan; Daniela Wieser; Xiaolei Xun; Rong Zhao; Thierry T Diagana; Peter Pertel; F Joel Leong Journal: N Engl J Med Date: 2016-09-22 Impact factor: 91.245
Authors: Brioni R Moore; Moses Laman; Sam Salman; Kevin T Batty; Madhu Page-Sharp; Francis Hombhanje; Laurens Manning; Timothy M E Davis Journal: Drugs Date: 2016-05 Impact factor: 9.546
Authors: Francis W Hombhanje; David Linge; Adolf Saweri; Cynthia Kuanch; Robert Jones; Stephen Toraso; Jacobed Geita; Andrew Masta; Isi Kevau; Gilbert Hiawalyer; Mathias Sapuri Journal: Malar J Date: 2009-08-12 Impact factor: 2.979