Literature DB >> 14627380

A new synthetic approach to the C ring of known as well as novel bryostatin analogues.

Paul A Wender1, Michael F T Koehler, Martin Sendzik.   

Abstract

[reaction: see text] A new approach to the synthesis of the C ring subunit of known and potential bryostatin analogues is described. The convergent approach, illustrated above, requires fewer steps and offers greater flexibility in rapidly accessing diverse C ring analogues.

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Year:  2003        PMID： 14627380     DOI： 10.1021/ol0355332

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  6 in total

1.  Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues.

Authors:  Thomas J Cummins; Noemi Kedei; Agnes Czikora; Nancy E Lewin; Sharon Kirk; Mark E Petersen; Kevin M McGowan; Jin-Qiu Chen; Xiaoling Luo; Randall C Johnson; Sarangan Ravichandran; Peter M Blumberg; Gary E Keck
Journal:  Chembiochem       Date:  2018-03-25       Impact factor: 3.164

2.  The scope and mechanism of palladium-catalysed Markovnikov alkoxycarbonylation of alkenes.

Authors:  Haoquan Li; Kaiwu Dong; Haijun Jiao; Helfried Neumann; Ralf Jackstell; Matthias Beller
Journal:  Nat Chem       Date:  2016-09-05       Impact factor: 24.427

3.  Enantio- and diastereoselective additions to aldehydes using the bifunctional reagent 2-(chloromethyl)-3-(tributylstannyl)propene: application to a synthesis of the C16-C27 segment of bryostatin 1.

Authors:  Gary E Keck; Tao Yu; Mark D McLaws
Journal:  J Org Chem       Date:  2005-04-01       Impact factor: 4.354

4.  Aldolase-Catalyzed Asymmetric Synthesis of N-Heterocycles by Addition of Simple Aliphatic Nucleophiles to Aminoaldehydes.

Authors:  Raquel Roldán; Karel Hernández; Jesús Joglar; Jordi Bujons; Teodor Parella; Wolf-Dieter Fessner; Pere Clapés
Journal:  Adv Synth Catal       Date:  2019-02-15       Impact factor: 5.837

5.  Iodine/water-mediated deprotective oxidation of allylic ethers to access α,β-unsaturated ketones and aldehydes.

Authors:  Yuntian Xue; Yaolong Yan; Kezhi Jiang; Weifeng Chen; Lei Yang
Journal:  RSC Adv       Date:  2020-04-14       Impact factor: 3.361

6.  Synthesis of a des-B-ring bryostatin analogue leads to an unexpected ring expansion of the bryolactone core.

Authors:  Matthew B Kraft; Yam B Poudel; Noemi Kedei; Nancy E Lewin; Megan L Peach; Peter M Blumberg; Gary E Keck
Journal:  J Am Chem Soc       Date:  2014-09-10       Impact factor: 15.419
  6 in total

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