| Literature DB >> 14627339 |
Masatsugu Okuyama1, Yasuhiro Fujiwara, Tsuyoshi Hayakawa, Masatsugu Shiba, Toshio Watanabe, Kazunari Tominaga, Akihiro Tamori, Nobuhide Oshitani, Kazuhide Higuchi, Takayuki Matsumoto, Kenji Nakamura, Kenichi Wakasa, Kazuhiro Hirohashi, Shingo Ashida, Taro Shuin, Tetsuo Arakawa.
Abstract
Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited disorder characterized by extensively vascularized tumors and cysts in specific organs. Angiogenesis is a striking future of VHL disease with its characteristic cysts and well-vascularized tumors. The hypervascular nature of VHL lesions has been linked to the overproduciton of vascular endothelial growth factor (VEGF) through increased expression of hypoxia inducible factor-1alpha (HIF-1alpha). Here we describe a rare case of VHL disease with esophageal and gastric varices due to arterioportal shunt in a serous cystadenoma of the pancreas, which, upon immunohistochemical examination, exhibited HIF-1alpha and VEGF expression. Rupture of esophageal varices was successfully treated with endoscopic injection sclerotherapy.Entities:
Mesh：
Substances：
Year: 2003 PMID： 14627339 DOI： 10.1023/a:1026262019552
Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199