| Literature DB >> 14627334 |
Shin-Ichi Fujioka1, Hiroyuki Shimomura, Yoshiaki Iwasaki, Kozo Fujio, Hiroshi Nakagawa, Yasuhiro Onishi, Shinjiro Takagi, Hideaki Taniguchi, Fumi Umeoka, Hirofumi Nakajima, Akio Moriya, Katsuyuki Nanba, Cheng-Yu Piao, Toshiyuki Shinji, Norio Koide, Yasush Shiratori.
Abstract
The hepatitis B virus (HBV) gene has been detected in hepatocellular carcinoma (HCC) tissue negative for the hepatitis B surface antigen and positive for the hepatitis C virus (HCV) antibody, but the precise role of the HBV gene in hepatocarcinogenesis has yet to be clarified. We studied the HBV gene in liver tissue several years before the emergence of HCC. Eleven patients diagnosed with HCV-positive chronic liver disease and who developed HCC were assigned to group A. HBV DNA was detected in 8 of the 11 patients (73%). Twenty-five patients, who did not develop HCC, were selected as group B. Six of the group B patients were classified as DNA-positive (24%). The HBV DNA in liver tissue was found to be significantly related to HCC development (P < 0.01). Thus, the presence of the HBV gene in patients with chronic HCV associated-liver injury appears to promote hepatocarcinogenesis, although prospective studies are needed to confirm this result.Entities:
Mesh：
Year: 2003 PMID： 14627334 DOI： 10.1023/a:1026153800896
Source DB: PubMed Journal: Dig Dis Sci ISSN： 0163-2116 Impact factor: 3.199