Renee A Ahrens1, Matthew Hower, Al M Best. 1. Bernard J. Dunn School of Pharmacy, Shenandoah University, 1460 University Drive, Winchester, VA 22601, USA. rahrens@su.edu
Abstract
OBJECTIVE: To compare a meal replacement (MR) program with a conventional reduced-calorie diet (RCD) for weight management using the pharmacy as the setting and the pharmacist as the point of contact for dietary advice. DESIGN: Randomized, controlled, open-label trial. SETTING: Travis Pharmacy in Shenandoah, Iowa. PATIENTS: Ninety-five patients from southwestern iowa and southeastern Nebraska were enrolled, of whom 88 were considered eligible for comparison (by continuing through week 2 of the study). INTERVENTION: Patients were randomized to an MR plan or a traditional RCD plan. Patients were followed for a 3-month period of active weight loss and a 10-week period of weight maintenance. Patients returned every 3 weeks for follow-up with the pharmacist, for a total of 13 visits. MAIN OUTCOME MEASURE: Weight changes. RESULTS: During the active weight loss phase, the MR (n = 45) and RCD (n = 43) groups lost a significant amount of weight, although no significant difference was found between the groups (mean +/- standard error = 4.90 +/- 0.30 kg MR versus 4.30 +/- 0.30 kg RCD; P = .16). In the weight maintenance phase, the MR group lost 0.70 +/- 0.40 kg and the RCD group lost 0.90 +/- 0.40 kg (P = .60). Significant improvements were observed in waist circumference, systolic and diastolic blood pressure, and triglyceride levels. No significant changes were seen in high-density lipoprotein cholesterol or low-density lipoprotein cholesterol levels in either group. CONCLUSION: Successful weight management can be achieved in a pharmacy setting. Both MR and RCD programs were effective.
RCT Entities:
OBJECTIVE: To compare a meal replacement (MR) program with a conventional reduced-calorie diet (RCD) for weight management using the pharmacy as the setting and the pharmacist as the point of contact for dietary advice. DESIGN: Randomized, controlled, open-label trial. SETTING: Travis Pharmacy in Shenandoah, Iowa. PATIENTS: Ninety-five patients from southwestern iowa and southeastern Nebraska were enrolled, of whom 88 were considered eligible for comparison (by continuing through week 2 of the study). INTERVENTION: Patients were randomized to an MR plan or a traditional RCD plan. Patients were followed for a 3-month period of active weight loss and a 10-week period of weight maintenance. Patients returned every 3 weeks for follow-up with the pharmacist, for a total of 13 visits. MAIN OUTCOME MEASURE: Weight changes. RESULTS: During the active weight loss phase, the MR (n = 45) and RCD (n = 43) groups lost a significant amount of weight, although no significant difference was found between the groups (mean +/- standard error = 4.90 +/- 0.30 kg MR versus 4.30 +/- 0.30 kg RCD; P = .16). In the weight maintenance phase, the MR group lost 0.70 +/- 0.40 kg and the RCD group lost 0.90 +/- 0.40 kg (P = .60). Significant improvements were observed in waist circumference, systolic and diastolic blood pressure, and triglyceride levels. No significant changes were seen in high-density lipoprotein cholesterol or low-density lipoprotein cholesterol levels in either group. CONCLUSION: Successful weight management can be achieved in a pharmacy setting. Both MR and RCD programs were effective.
Authors: Kimberly A Gudzune; Ruchi S Doshi; Ambereen K Mehta; Zoobia W Chaudhry; David K Jacobs; Rachit M Vakil; Clare J Lee; Sara N Bleich; Jeanne M Clark Journal: Ann Intern Med Date: 2015-04-07 Impact factor: 25.391
Authors: Lynne Doner Lotenberg; Lisa C Clough; Thomas A Mackey; Amy E Rudolph; Rita Samuel; JoAnne M Foody Journal: J Clin Hypertens (Greenwich) Date: 2013-04-29 Impact factor: 3.738
Authors: Liz Steed; Ratna Sohanpal; Adam Todd; Vichithranie W Madurasinghe; Carol Rivas; Elizabeth A Edwards; Carolyn D Summerbell; Stephanie Jc Taylor; R T Walton Journal: Cochrane Database Syst Rev Date: 2019-12-06