Literature DB >> 14625885

RNA interference: on the road to an alternate therapeutic strategy!

Rajnish S Dave1, Roger J Pomerantz.   

Abstract

RNA interference (RNAi) is a newly described natural biological phenomenon mediated by small interfering RNA (siRNA) molecules which target viral mRNA for degradation by cellular enzymes. RNAi has become a method of choice for studying gene function, especially in mammalian systems. With proof-of-concept studies already presented against a wide variety of human pathogens and several innovative methods of delivering the siRNA to a wide variety of primary cells available, the role for siRNA as a potential therapeutic strategy is becoming increasingly clear. This review presents recent advances in this direction. Copyright 2003 John Wiley & Sons, Ltd.

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Year:  2003        PMID： 14625885     DOI： 10.1002/rmv.407

Source DB:  PubMed          Journal:  Rev Med Virol        ISSN： 1052-9276            Impact factor:   6.989


  15 in total

1.  RNA interference against animal viruses: how morbilliviruses generate extended diversity to escape small interfering RNA control.

Authors:  Carine L Holz; Emmanuel Albina; Cécile Minet; Renaud Lancelot; Olivier Kwiatek; Geneviève Libeau; Renata Servan de Almeida
Journal:  J Virol       Date:  2011-11-09       Impact factor: 5.103

2.  The cellular HIV-1 Rev cofactor hRIP is required for viral replication.

Authors:  Zhong Yu; Nuria Sánchez-Velar; Irina E Catrina; Ellen L W Kittler; Enyeneama B Udofia; Maria L Zapp
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-04       Impact factor: 11.205

3.  Lentiviral delivery of short hairpin RNAs protects CD4 T cells from multiple clades and primary isolates of HIV.

Authors:  Sang-Kyung Lee; Derek M Dykxhoorn; Priti Kumar; Shahin Ranjbar; Erwei Song; Laura E Maliszewski; Vanessa François-Bongarçon; Anne Goldfeld; N Manjunath Swamy; Judy Lieberman; Premlata Shankar
Journal:  Blood       Date:  2005-04-14       Impact factor: 22.113

Review 4.  Tumor-targeted delivery of siRNA by non-viral vector: safe and effective cancer therapy.

Authors:  Yunching Chen; Leaf Huang
Journal:  Expert Opin Drug Deliv       Date:  2008-12       Impact factor: 6.648

5.  Antiviral effects of human immunodeficiency virus type 1-specific small interfering RNAs against targets conserved in select neurotropic viral strains.

Authors:  Rajnish S Dave; Roger J Pomerantz
Journal:  J Virol       Date:  2004-12       Impact factor: 5.103

6.  Requirement for sphingosine 1-phosphate receptor-1 in tumor angiogenesis demonstrated by in vivo RNA interference.

Authors:  Sung-Suk Chae; Ji-Hye Paik; Henry Furneaux; Timothy Hla
Journal:  J Clin Invest       Date:  2004-10       Impact factor: 14.808

7.  Lentivirus-mediated RNA interference of vascular endothelial growth factor in monkey eyes with iris neovascularization.

Authors:  Meng-Ke Yuan; Yong Tao; Wen-Zhen Yu; Wang Kai; Yan-Rong Jiang
Journal:  Mol Vis       Date:  2010-08-25       Impact factor: 2.367

8.  Inhibitory effect of vascular endothelial growth factors-targeted small interfering RNA on proliferation of gastric cancer cells.

Authors:  Wen-Hua Xu; Yin-Lin Ge; Quan Li; Xiao Zhang; Jian-Hua Duan
Journal:  World J Gastroenterol       Date:  2007-04-14       Impact factor: 5.742

9.  Internally cationic polyamidoamine PAMAM-OH dendrimers for siRNA delivery: effect of the degree of quaternization and cancer targeting.

Authors:  Mahesh L Patil; Min Zhang; Oleh Taratula; Olga B Garbuzenko; Huixin He; Tamara Minko
Journal:  Biomacromolecules       Date:  2009-02-09       Impact factor: 6.988

10.  Inhibiting colorectal carcinoma growth and metastasis by blocking the expression of VEGF using RNA interference.

Authors:  Shaochuang Wang; Hui Liu; Lifeng Ren; Yifeng Pan; Yangde Zhang
Journal:  Neoplasia       Date:  2008-04       Impact factor: 5.715
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