Literature DB >> 14625152

Sleep pathophysiology in posttraumatic stress disorder and idiopathic nightmare sufferers.

Anne Germain1, Tore A Nielsen.   

Abstract

BACKGROUND: Nightmares are common in posttraumatic stress disorder (PTSD), but they also frequently occur in idiopathic form. Findings associated with sleep disturbances in these two groups have been inconsistent, and sparse for idiopathic nightmares. The aim of the present study was to investigate whether sleep anomalies in PTSD sufferers with frequent nightmares (P-NM) differ from those observed in non-PTSD, idiopathic nightmare (I-NM) sufferers and healthy individuals.
METHODS: Sleep measures were obtained from nine P-NM sufferers, 11 I-NM sufferers, and 13 healthy control subjects. All participants slept in the laboratory for two consecutive nights where electroencephalogram, electro-oculogram, chin and leg electromyogram, electrocardiogram, and respiration were recorded continuously.
RESULTS: Posttraumatic nightmare sufferers had significantly more nocturnal awakenings than did I-NM sufferers and control subjects. Elevated indices of periodic leg movements (PLMs) during rapid eye movement (REM) and non-REM sleep characterized both P-NM and I-NM sufferers.
CONCLUSIONS: Posttraumatic nightmare sufferers exhibit more nocturnal awakenings than do I-NM sufferers and control subjects, which supports the hypothesis of hyperarousal in sleep in PTSD sufferers; however, elevated PLM indices in both P-NM and I-NM sufferers suggest that PLMs may not be a marker of hyperarousal in sleep of PTSD sufferers. Rather, PLMs may be a correlate of processes contributing to intense negative dreaming.

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Year:  2003        PMID: 14625152     DOI: 10.1016/s0006-3223(03)00071-4

Source DB:  PubMed          Journal:  Biol Psychiatry        ISSN: 0006-3223            Impact factor:   13.382


  39 in total

1.  Sleep physiology, abnormal States, and therapeutic interventions.

Authors:  Alvah T Wickboldt; Alex F Bowen; Aaron J Kaye; Adam M Kaye; Franklin Rivera Bueno; Alan D Kaye
Journal:  Ochsner J       Date:  2012

2.  Best practice guide for the treatment of nightmare disorder in adults.

Authors:  R Nisha Aurora; Rochelle S Zak; Sanford H Auerbach; Kenneth R Casey; Susmita Chowdhuri; Anoop Karippot; Rama K Maganti; Kannan Ramar; David A Kristo; Sabin R Bista; Carin I Lamm; Timothy I Morgenthaler
Journal:  J Clin Sleep Med       Date:  2010-08-15       Impact factor: 4.062

3.  Placebo-controlled comparison of prazosin and cognitive-behavioral treatments for sleep disturbances in US Military Veterans.

Authors:  Anne Germain; Robin Richardson; Douglas E Moul; Oommen Mammen; Gretchen Haas; Steven D Forman; Noelle Rode; Amy Begley; Eric A Nofzinger
Journal:  J Psychosom Res       Date:  2011-12-20       Impact factor: 3.006

4.  Evening-type military veterans report worse lifetime posttraumatic stress symptoms and greater brainstem activity across wakefulness and REM sleep.

Authors:  Brant P Hasler; Salvatore P Insana; Jeffrey A James; Anne Germain
Journal:  Biol Psychol       Date:  2013-07-02       Impact factor: 3.251

5.  Neurophysiological correlates of suicidal ideation in major depressive disorder: Hyperarousal during sleep.

Authors:  Michael R Dolsen; Philip Cheng; J Todd Arnedt; Leslie Swanson; Melynda D Casement; Hyang Sook Kim; Jennifer R Goldschmied; Robert F Hoffmann; Roseanne Armitage; Patricia J Deldin
Journal:  J Affect Disord       Date:  2017-01-26       Impact factor: 4.839

6.  Disturbed dreaming and the instability of sleep: altered nonrapid eye movement sleep microstructure in individuals with frequent nightmares as revealed by the cyclic alternating pattern.

Authors:  Péter Simor; Róbert Bódizs; Klára Horváth; Raffaele Ferri
Journal:  Sleep       Date:  2013-03-01       Impact factor: 5.849

Review 7.  Sleep disturbances in patients with post-traumatic stress disorder: epidemiology, impact and approaches to management.

Authors:  Michael J Maher; Simon A Rego; Gregory M Asnis
Journal:  CNS Drugs       Date:  2006       Impact factor: 5.749

Review 8.  Sleep and mental disorders: A meta-analysis of polysomnographic research.

Authors:  Chiara Baglioni; Svetoslava Nanovska; Wolfram Regen; Kai Spiegelhalder; Bernd Feige; Christoph Nissen; Charles F Reynolds; Dieter Riemann
Journal:  Psychol Bull       Date:  2016-07-14       Impact factor: 17.737

9.  Effects of stressor controllability on diurnal physiological rhythms.

Authors:  Robert S Thompson; John P Christianson; Thomas M Maslanik; Steve F Maier; Benjamin N Greenwood; Monika Fleshner
Journal:  Physiol Behav       Date:  2013-02-27

Review 10.  Sleep disturbances as the hallmark of PTSD: where are we now?

Authors:  Anne Germain
Journal:  Am J Psychiatry       Date:  2013-04       Impact factor: 18.112

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