| Literature DB >> 14625088 |
Paromita Das1, Glenn H Dillon.
Abstract
There are currently no known agents that display selectivity between homomeric 5-hydroxytryptamine type 3A (5-HT3A) and heteromeric 5-HT3A/3B receptors. In the present study, we show that the CNS convulsant picrotoxin selectively interacts with 5-HT3A receptors. In whole-cell patch clamp recordings, the inhibitory effect of PTX was reduced 100-fold in heteromeric mouse 5-HT3A/3B receptors, compared to homomeric 5-HT3A receptors. Picrotoxin should prove to be a useful probe for determining the presence of homomeric vs. heteromeric 5-HT3 receptors in both native tissue and recombinant receptor preparations.Entities:
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Year: 2003 PMID： 14625088 DOI： 10.1016/j.molbrainres.2003.09.003
Source DB: PubMed Journal: Brain Res Mol Brain Res ISSN： 0169-328X