| Literature DB >> 14625068 |
Yoshinori Yajima1, Minoru Narita, Masahiro Shimamura, Michiko Narita, Chiharu Kubota, Tsutomu Suzuki.
Abstract
In the present study, we demonstrated the differential role of spinal protein kinases in neuropathic and inflammatory pain. Mice with sciatic nerve ligation exhibited a spinal protein kinase C (PKC)-dependent neuropathic pain-like state. In contrast, an intraplanter injection of inflammatory agent caused a protein kinase A (PKA)-related thermal hyperalgesia. These findings suggest that the substantial activation of spinal PKC and PKA may differentially contribute to the development of respective chronic pain-like state in mice.Entities:
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Year: 2003 PMID： 14625068 DOI： 10.1016/j.brainres.2003.08.042
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252