| Literature DB >> 14625009 |
Masaaki Tanaka1, Fusao Nakamura, Shigekazu Mizokawa, Akira Matsumura, Satoshi Nozaki, Yasuyoshi Watanabe.
Abstract
To establish an animal model of fatigue, we kept rats in a cage filled with water to a height of 1.5 cm. We selected a weight-loaded forced swimming test for evaluation of the extent of fatigue. Animals kept in the wet cage for 5 days showed a reduction in 2-[18F]fluoro-2-deoxy-D-glucose uptake into their brain. The session for 1 day showed significantly increased 5-hydroxyindoleacetic acid (5-HIAA)/5-hydroxytryptamine (5-HT) and [3,4-dihydroxyphenyl-acetic acid (DOPAC)+homovanillic acid (HVA)]/dopamine (DA) ratios in all brain regions, but the session for 5 days showed the restoration of the 5-HIAA/5-HT ratio in the hippocampus and hypothalamus and in the (DOPAC+HVA)/DA ratio in the striatum and hypothalamus. Our data suggest that decreased glucose uptake and insufficient serotonin and dopamine turnover introduced by deprivation of rest were correlated with central fatigue.Entities:
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Year: 2003 PMID： 14625009 DOI： 10.1016/j.neulet.2003.08.051
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046