Literature DB >> 14624559

Gamma-allyl phosphinoyl phenyl sulfone (GAPPS): a conjunctive reagent for the synthesis of EE, EZ, and ET 1,3-dienes.

Xiaojin Li1, Douglas Lantrip, Philip L Fuchs.   

Abstract

A three-operation conjunctive strategy is available for the synthesis of EE, EZ, and ET dienes. This protocol employs a sequential Wadsworth-Emmons reaction using a GAPPS reagent followed by alkylation of an allylic sulfone anion, and finally ligand-mediated, palladium-catalyzed desulfonylation.

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Year:  2003        PMID： 14624559     DOI： 10.1021/ja0377596

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  2 in total

1.  Synthesis of (2R,8' S,3' E)-δ-tocodienol, a tocoflexol family member designed to have a superior pharmacokinetic profile compared to δ-tocotrienol.

Authors:  Xingui Liu; Satheesh Gujarathi; Xuan Zhang; Lijian Shao; Marjan Boerma; Cesar M Compadre; Peter A Crooks; Martin Hauer-Jensen; Daohong Zhou; Guangrong Zheng
Journal:  Tetrahedron       Date:  2016-05-12       Impact factor: 2.457

2.  Preparation of β2-Homologous Amino Acids Bearing Polar Side Chains via a Collective Synthesis Strategy.

Authors:  Shi Liu; Samuel H Gellman
Journal:  J Org Chem       Date:  2020-01-10       Impact factor: 4.354
  2 in total

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