BACKGROUND: beta-Amyloid peptide (Abeta), a neutrotoxic substance, has been implicated to a great degree in cell death during the course of AD. Resveratrol, a natural polyphenol mainly found in red wine, has been shown to be cardioprotective and chemoprotective. Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol. OBJECTIVE: The present study aimed at elucidating the possible neuroprotective effects of resveratrol against Abeta-induced neurotoxicity. METHODS: The neuroprotective capacity against Abeta-related oxidative stress was studied in a cell culture model suitable for studying such potentially neuroprotective substances. RESULTS: Resveratrol maintains cell viability and exerts an anti-oxidative action by enhancing the intracellular free-radical scavenger glutathione. CONCLUSION: Our findings suggest that red wine may be neuroprotective through the actions of resveratrol. Copyright 2003 S. Karger AG, Basel
BACKGROUND:beta-Amyloid peptide (Abeta), a neutrotoxic substance, has been implicated to a great degree in cell death during the course of AD. Resveratrol, a natural polyphenol mainly found in red wine, has been shown to be cardioprotective and chemoprotective. Since a moderate wine intake correlates with a lower risk for Alzheimer disease (AD), an additional neuroprotective effect has been postulated for resveratrol. OBJECTIVE: The present study aimed at elucidating the possible neuroprotective effects of resveratrol against Abeta-induced neurotoxicity. METHODS: The neuroprotective capacity against Abeta-related oxidative stress was studied in a cell culture model suitable for studying such potentially neuroprotective substances. RESULTS:Resveratrol maintains cell viability and exerts an anti-oxidative action by enhancing the intracellular free-radical scavenger glutathione. CONCLUSION: Our findings suggest that red wine may be neuroprotective through the actions of resveratrol. Copyright 2003 S. Karger AG, Basel
Authors: Balenahalli N Ramesh; T S Sathyanarayana Rao; Annamalai Prakasam; Kumar Sambamurti; K S Jagannatha Rao Journal: J Alzheimers Dis Date: 2010 Impact factor: 4.472
Authors: S Gillette Guyonnet; G Abellan Van Kan; S Andrieu; J P Aquino; C Arbus; J P Becq; C Berr; S Bismuth; B Chamontin; T Dantoine; J F Dartigues; B Dubois; B Fraysse; T Hergueta; H Hanaire; C Jeandel; S Lagleyre; F Lala; F Nourhashemi; P J Ousset; F Portet; P Ritz; P Robert; Y Rolland; C Sanz; M Soto; J Touchon; B Vellas Journal: J Nutr Health Aging Date: 2008-10 Impact factor: 4.075
Authors: Valérie Vingtdeux; Luca Giliberto; Haitian Zhao; Pallavi Chandakkar; Qingli Wu; James E Simon; Elsa M Janle; Jessica Lobo; Mario G Ferruzzi; Peter Davies; Philippe Marambaud Journal: J Biol Chem Date: 2010-01-14 Impact factor: 5.157