Nasal septal perforation repair with porcine small intestinal submucosa.

Repair of nasal septal perforations presents a difficult challenge to the otolaryngologist. Successful closure rates of greater than 90% have been published by several authors using bipedicled mucoperichondrial advancement flaps and interpositional grafts. A number of different materials, both autografts and allografts, have been used as interpositional grafts. We report a 100% closure rate (10 of 10) using an open rhinoplasty technique with bipedicled advancement flaps and porcine small intestinal submucosa (SurgiSIS; Cook Biotech Inc, West Lafayette, Ind) as an interpositional graft. We submit that SurgiSIS is an ideal material for use in the repair of nasal septal perforations because it is easy to work with, demonstrates the ability to support the regeneration of adjacent tissue, and avoids the increased operative time and morbidity associated with harvesting autografts.