Literature DB >> 14623615

HPLC and HPTLC assays for the antimalarial agents chloroquine, primaquine and bulaquine.

A K Dwivedi1, D Saxena, S Singh.   

Abstract

A combination Kit for antirelapse treatment of P. vivax malaria, consisting of Chloroquine phosphate tablets and Bulaquine capsules has been recently developed, and marketed under the trade name Aablaquine. Bulaquine is prepared from Primaquine. Several methods of analysis are reported for each drug separately as well two drugs in combination but no method for simultaneous estimation of these three drugs is known. Therefore, the present study was undertaken to develop a sensitive and reproducible high performance liquid chromatographic as well as high performance thin layer chromatographic assay method for the simultaneous estimation of Chloroquine, Primaquine and Bulaquine.

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Year:  2003        PMID： 14623615     DOI： 10.1016/s0731-7085(03)00355-8

Source DB:  PubMed          Journal:  J Pharm Biomed Anal        ISSN： 0731-7085            Impact factor:   3.935


  5 in total

1.  Simultaneous and enantiospecific quantification of primaquine and carboxyprimaquine in human plasma using liquid chromatography-tandem mass spectrometry.

Authors:  Warunee Hanpithakpong; Nicholas P J Day; Nicholas J White; Joel Tarning
Journal:  Malar J       Date:  2022-06-03       Impact factor: 3.469

2.  Electrospray ionization-ion trap mass spectrometry study of PQAAPro and PQProAA mimetic derivatives of the antimalarial primaquine.

Authors:  Nuno Vale; Joana Matos; Rui Moreira; Paula Gomes
Journal:  J Am Soc Mass Spectrom       Date:  2008-07-01       Impact factor: 3.109

Review 3.  HPLC methods for choloroquine determination in biological samples and pharmaceutical products.

Authors:  Yugo Araújo Martins; Talita Mota Gonçalves; Renata F V Lopez
Journal:  Daru       Date:  2021-03-19       Impact factor: 3.117

4.  Simultaneous quantitation of chloroquine and primaquine by UPLC-DAD and comparison with a HPLC-DAD method.

Authors:  Tiago A Miranda; Pedro H R Silva; Gerson A Pianetti; Isabela C César
Journal:  Malar J       Date:  2015-01-28       Impact factor: 2.979

5.  Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry.

Authors:  Bharathi Avula; Babu L Tekwani; Narayan D Chaurasiya; Pius Fasinu; N P Dhammika Nanayakkara; H M T Bhandara Herath; Yan-Hong Wang; Ji-Yeong Bae; Shabana I Khan; Mahmoud A Elsohly; James D McChesney; Peter A Zimmerman; Ikhlas A Khan; Larry A Walker
Journal:  Malar J       Date:  2018-08-13       Impact factor: 2.979
  5 in total

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