Literature DB >> 14623080

Glyoxalase I of the malarial parasite Plasmodium falciparum: evidence for subunit fusion.

Rimma Iozef1, Stefan Rahlfs, Tammy Chang, Heiner Schirmer, Katja Becker.   

Abstract

Recombinant Plasmodium falciparum glyoxalase I (PfGlx I) was characterized as monomeric Zn(2+)-containing enzyme of 44 kDa. The K(M) value of the methylglyoxal-glutathione adduct is 77+/-15 microM, the k(cat) value being 4000 min(-1) at 25 degrees C and pH 7.0. PfGlx I consists of two halves, each of which is homologous to the small 2-domain glyoxalase I of man. Both parts of the pfglx I gene were overexpressed; the C-terminal half of PfGlx I was found to be a stable protein and formed an enzymatically active dimer. These results support the hypothesis of domain-swapping and subunit fusion as mechanisms in glyoxalase I evolution.

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Year:  2003        PMID： 14623080     DOI： 10.1016/s0014-5793(03)01146-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  10 in total

1.  Structure of the novel monomeric glyoxalase I from Zea mays.

Authors:  Gino L Turra; Romina B Agostini; Carolina M Fauguel; Daniel A Presello; Carlos S Andreo; Javier M González; Valeria A Campos-Bermudez
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2015-09-26

2.  Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of glyoxalase I from Leishmania infantum.

Authors:  Lídia Barata; Marta Sousa Silva; Linda Schuldt; Gonçalo da Costa; Ana M Tomás; António E N Ferreira; Manfred S Weiss; Ana Ponces Freire; Carlos Cordeiro
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2010-04-30

3.  Structural variation in bacterial glyoxalase I enzymes: investigation of the metalloenzyme glyoxalase I from Clostridium acetobutylicum.

Authors:  Uthaiwan Suttisansanee; Kelvin Lau; Satyanarayana Lagishetty; Krishnamurthy N Rao; Subramanyam Swaminathan; J Michael Sauder; Stephen K Burley; John F Honek
Journal:  J Biol Chem       Date:  2011-09-13       Impact factor: 5.157

4.  A trypanothione-dependent glyoxalase I with a prokaryotic ancestry in Leishmania major.

Authors:  Tim J Vickers; Neil Greig; Alan H Fairlamb
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-25       Impact factor: 11.205

5.  Distinct classes of glyoxalase I: metal specificity of the Yersinia pestis, Pseudomonas aeruginosa and Neisseria meningitidis enzymes.

Authors:  Nicole Sukdeo; Susan L Clugston; Elisabeth Daub; John F Honek
Journal:  Biochem J       Date:  2004-11-15       Impact factor: 3.857

Review 6.  Nonredox nickel enzymes.

Authors:  Michael J Maroney; Stefano Ciurli
Journal:  Chem Rev       Date:  2013-12-26       Impact factor: 60.622

7.  Crystallization and preliminary X-ray analysis of Leishmania major glyoxalase I.

Authors:  Antonio Ariza; Tim J Vickers; Neil Greig; Alan H Fairlamb; Charles S Bond
Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun       Date:  2005-07-30

8.  Arabidopsis thaliana Contains Both Ni2+ and Zn2+ Dependent Glyoxalase I Enzymes and Ectopic Expression of the Latter Contributes More towards Abiotic Stress Tolerance in E. coli.

Authors:  Muskan Jain; Rituraj Batth; Sumita Kumari; Ananda Mustafiz
Journal:  PLoS One       Date:  2016-07-14       Impact factor: 3.240

9.  Antioxidant defense in Plasmodium falciparum--data mining of the transcriptome.

Authors:  Zbynek Bozdech; Hagai Ginsburg
Journal:  Malar J       Date:  2004-07-09       Impact factor: 2.979

10.  Episodes of horizontal gene-transfer and gene-fusion led to co-existence of different metal-ion specific glyoxalase I.

Authors:  Charanpreet Kaur; Anchal Vishnoi; Thilini Udayangani Ariyadasa; Alok Bhattacharya; Sneh Lata Singla-Pareek; Sudhir Kumar Sopory
Journal:  Sci Rep       Date:  2013-11-13       Impact factor: 4.379
  10 in total

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