| Literature DB >> 14623010 |
James Siedlecki1, Jason Hill, Ian Parr, Xiang Yu, Michael Morytko, Yanzhi Zhang, Jared Silverman, Nicole Controneo, Valerie Laganas, Tongchuan Li, Jianshi Li, Dennis Keith, George Shimer, John Finn.
Abstract
Synthetic array technology was utilized to rapidly synthesize and analyze a diverse set of reductive alkylation analogues of daptomycin. Analysis of the array suggested the use of polar functionality such as sulfonamides or amide or polar spaces such as piperazine would beneficially affect activity.Entities:
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Year: 2003 PMID： 14623010 DOI： 10.1016/j.bmcl.2003.07.025
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823