| Literature DB >> 14622999 |
Lisa M Thomasco1, Robert C Gadwood, Elizabeth A Weaver, Jason M Ochoada, Charles W Ford, Gary E Zurenko, Judith C Hamel, Douglas Stapert, Judy K Moerman, Ronda D Schaadt, Betty H Yagi.
Abstract
Replacement of the morpholine C-ring of linezolid 1 with a 1,3,4-thiadiazolyl ring leads to oxazolidinone analogues 5 having potent antibacterial activity against both gram-positive and gram-negative organisms. Conversion of the C5 acetamide group to a thioacetamide further increases the potency of these compounds.Entities:
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Year: 2003 PMID： 14622999 DOI： 10.1016/j.bmcl.2003.07.018
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823