Literature DB >> 14622997

New classes of antibacterial oxazolidinones with C-5, methylene O-linked heterocyclic side chains.

Michael B Gravestock1, David G Acton, Michael J Betts, Michael Dennis, Glenn Hatter, Alexandra McGregor, Michael L Swain, R Geoffrey Wilson, Lisa Woods, Alan Wookey.   

Abstract

Exploration of the structure-activity relationships of the traditional C-5 acetamidomethyl side chain of the oxazolidonone antibacterials has yielded new, potent series of compounds of which the first examples, the O-linked iosoxazoles are described in detail, leading to the selection of the pre-clinical candidate AZD2563.

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Year:  2003        PMID： 14622997     DOI： 10.1016/j.bmcl.2003.07.033

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Recent Advances in the Rational Design and Optimization of Antibacterial Agents.

Authors:  Jesse A Jones; Kristopher G Virga; Giuseppe Gumina; Kirk E Hevener
Journal:  Medchemcomm       Date:  2016-07-07       Impact factor: 3.597

2.  Discovery of Fluorine-Containing Benzoxazinyl-oxazolidinones for the Treatment of Multidrug Resistant Tuberculosis.

Authors:  Hongyi Zhao; Yu Lu; Li Sheng; Zishuo Yuan; Bin Wang; Weiping Wang; Yan Li; Chen Ma; Xiaoliang Wang; Dongfeng Zhang; Haihong Huang
Journal:  ACS Med Chem Lett       Date:  2017-04-12       Impact factor: 4.345

3.  Structure-activity relationships of diverse oxazolidinones for linezolid-resistant Staphylococcus aureus strains possessing the cfr methyltransferase gene or ribosomal mutations.

Authors:  Jeffrey B Locke; John Finn; Mark Hilgers; Gracia Morales; Shahad Rahawi; Kedar G C; Juan José Picazo; Weonbin Im; Karen Joy Shaw; Jeffrey L Stein
Journal:  Antimicrob Agents Chemother       Date:  2010-09-13       Impact factor: 5.191

4.  Pharmacokinetic and pharmacodynamic evaluation of AZD5847 in a mouse model of tuberculosis.

Authors:  V Balasubramanian; Suresh Solapure; Radha Shandil; Sheshagiri Gaonkar; K N Mahesh; Jitender Reddy; Abhijeet Deshpande; Sowmya Bharath; Naveen Kumar; Lindsay Wright; David Melnick; Scott L Butler
Journal:  Antimicrob Agents Chemother       Date:  2014-05-12       Impact factor: 5.191

5.  In vitro and in vivo activities of three oxazolidinones against nonreplicating Mycobacterium tuberculosis.

Authors:  Ming Zhang; Claudia Sala; Neeraj Dhar; Anthony Vocat; Vasan K Sambandamurthy; Sreevalli Sharma; Gwendolyn Marriner; V Balasubramanian; Stewart T Cole
Journal:  Antimicrob Agents Chemother       Date:  2014-03-24       Impact factor: 5.191

6.  An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants.

Authors:  Wanida Phetsang; Mark A T Blaskovich; Mark S Butler; Johnny X Huang; Johannes Zuegg; Sreeman K Mamidyala; Soumya Ramu; Angela M Kavanagh; Matthew A Cooper
Journal:  Bioorg Med Chem       Date:  2014-06-14       Impact factor: 3.641
  6 in total

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