Cortical patches on the move.

Endocytosis is the primary means by which eukaryotic cells internalize materials from the environment. However, while many components of the endocytic machinery are known, the timing of molecular events leading to endocytosis remains undefined. In this issue of Cell, Kaksonen et al. use real-time microscopy to define the temporal assembly of components of the endocytic machinery in the yeast S. cerevisiae. They also provide new insight into how the actin cytoskeleton is coordinated with the endocytic machinery.