Literature DB >> 14620841

Polyhydroxyalkanoate (PHA) hemeostasis: the role of PHA synthase.

JoAnne Stubbe1, Jiamin Tian.   

Abstract

Polyhydroxyalkanoates (PHAs) are biodegradable polymers with properties of thermoplastics Production of these polymers in an economically competitive fashion via bioengineering requires an understanding of the biosynthetic pathway and its regulation. This review summarizes our current knowledge of the mechanism of the class I and III PHA synthases: the initiation, elongation and termination processes. It also summarizes our current understanding of the phase transition from soluble substrates (coenzyme A esters of beta-hydroxyalkanoates) to insoluble granules and our understanding of the requirement for a transcription factor, phasin proteins, and depolymerases in PHA homeostasis.

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Year:  2003        PMID： 14620841     DOI： 10.1039/b209687k

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  45 in total

1.  Inhibitors of polyhydroxyalkanoate (PHA) synthases: synthesis, molecular docking, and implications.

Authors:  Wei Zhang; Chao Chen; Ruikai Cao; Leila Maurmann; Ping Li
Journal:  Chembiochem       Date:  2014-11-13       Impact factor: 3.164

2.  Roles of multiple acetoacetyl coenzyme A reductases in polyhydroxybutyrate biosynthesis in Ralstonia eutropha H16.

Authors:  Charles F Budde; Alison E Mahan; Jingnan Lu; Chokyun Rha; Anthony J Sinskey
Journal:  J Bacteriol       Date:  2010-08-20       Impact factor: 3.490

3.  Molecular characterization of the phaECHm genes, required for biosynthesis of poly(3-hydroxybutyrate) in the extremely halophilic archaeon Haloarcula marismortui.

Authors:  Jing Han; Qiuhe Lu; Ligang Zhou; Jian Zhou; Hua Xiang
Journal:  Appl Environ Microbiol       Date:  2007-08-03       Impact factor: 4.792

Review 4.  Neutral lipid bodies in prokaryotes: recent insights into structure, formation, and relationship to eukaryotic lipid depots.

Authors:  Marc Wältermann; Alexander Steinbüchel
Journal:  J Bacteriol       Date:  2005-06       Impact factor: 3.490

Review 5.  Polyhydroxyalkanoate granules are complex subcellular organelles (carbonosomes).

Authors:  Dieter Jendrossek
Journal:  J Bacteriol       Date:  2009-03-06       Impact factor: 3.490

6.  Development of a transferable bimolecular fluorescence complementation system for the investigation of interactions between poly(3-hydroxybutyrate) granule-associated proteins in Gram-negative bacteria.

Authors:  Daniel Pfeiffer; Dieter Jendrossek
Journal:  Appl Environ Microbiol       Date:  2013-02-22       Impact factor: 4.792

7.  Engineered Fluorine Metabolism and Fluoropolymer Production in Living Cells.

Authors:  Benjamin W Thuronyi; Thomas M Privalsky; Michelle C Y Chang
Journal:  Angew Chem Int Ed Engl       Date:  2017-09-26       Impact factor: 15.336

8.  PhaP is involved in the formation of a network on the surface of polyhydroxyalkanoate inclusions in Cupriavidus necator H16.

Authors:  Douglas Dennis; Vicki Sein; Edgar Martinez; Brian Augustine
Journal:  J Bacteriol       Date:  2007-11-02       Impact factor: 3.490

9.  PhaM is the physiological activator of poly(3-hydroxybutyrate) (PHB) synthase (PhaC1) in Ralstonia eutropha.

Authors:  Daniel Pfeiffer; Dieter Jendrossek
Journal:  Appl Environ Microbiol       Date:  2013-11-08       Impact factor: 4.792

10.  Comparison of four phaC genes from Haloferax mediterranei and their function in different PHBV copolymer biosyntheses in Haloarcula hispanica.

Authors:  Jing Han; Ming Li; Jing Hou; Linping Wu; Jian Zhou; Hua Xiang
Journal:  Saline Syst       Date:  2010-08-20
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