| Literature DB >> 1462048 |
T Kurizaki1, H Egami, K Murata, H Kiyohara, S Okazaki, N Yoshida, M Ogawa.
Abstract
The effect of human membrane-associated phospholipase A2 (M-PLA2) on DNA synthesis in fibroblasts was examined in order to clarify its biological function. Human M-PLA2 added exogenously to the fibroblast cell lines Swiss 3T3 and BALB/3T3 was found to augment their DNA synthesis. This stimulation of DNA synthesis was not affected by treatment with indomethacin. Our results suggest that human M-PLA2 itself has a mitogenic effect on fibroblasts independent of arachidonate products such as prostaglandins.Entities:
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Year: 1992 PMID： 1462048
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164