Literature DB >> 14619456

Intravenous ascorbic acid: protocol for its application and use.

Hugh D Riordan1, Ronald B Hunninghake, Neil H Riordan, James J Jackson, Xiaolong Meng, Paul Taylor, Joseph J Casciari, Michael J González, Jorge R Miranda-Massari, Edna M Mora, Norberto Rosario, Alfredo Rivera.   

Abstract

High dose intravenous(i.v.) ascorbic acid (AA) has been used as therapy for infectious disease from bacterial and viral origin and adjuvant therapy for cancer. In this publication we describe a clinical protocol that has been developed over the past twenty years utilizing high dose i.v. AA as therapy for cancer. This includes principles of treatment, rationale, baseline workup, infusion protocol, precautions and side effects.

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Year:  2003        PMID: 14619456

Source DB:  PubMed          Journal:  P R Health Sci J        ISSN: 0738-0658            Impact factor:   0.705


  17 in total

1.  Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues.

Authors:  Qi Chen; Michael Graham Espey; Murali C Krishna; James B Mitchell; Christopher P Corpe; Garry R Buettner; Emily Shacter; Mark Levine
Journal:  Proc Natl Acad Sci U S A       Date:  2005-09-12       Impact factor: 11.205

2.  Noninvasive quantification of human brain antioxidant concentrations after an intravenous bolus of vitamin C.

Authors:  Melissa Terpstra; Carolyn Torkelson; Uzay Emir; James S Hodges; Susan Raatz
Journal:  NMR Biomed       Date:  2010-11-30       Impact factor: 4.044

3.  Nutrition and cancer: a review of the evidence for an anti-cancer diet.

Authors:  Michael S Donaldson
Journal:  Nutr J       Date:  2004-10-20       Impact factor: 3.271

Review 4.  Treatment of Pancreatic Cancer with Pharmacological Ascorbate.

Authors:  John A Cieslak; Joseph J Cullen
Journal:  Curr Pharm Biotechnol       Date:  2015       Impact factor: 2.837

5.  Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress.

Authors:  Christoph Klingelhoeffer; Ulrike Kämmerer; Monika Koospal; Bettina Mühling; Manuela Schneider; Michaela Kapp; Alexander Kübler; Christoph-Thomas Germer; Christoph Otto
Journal:  BMC Complement Altern Med       Date:  2012-05-02       Impact factor: 3.659

6.  High-dose intravenous vitamin C combined with cytotoxic chemotherapy in patients with advanced cancer: a phase I-II clinical trial.

Authors:  L John Hoffer; Line Robitaille; Robert Zakarian; David Melnychuk; Petr Kavan; Jason Agulnik; Victor Cohen; David Small; Wilson H Miller
Journal:  PLoS One       Date:  2015-04-07       Impact factor: 3.240

Review 7.  The effects of high concentrations of vitamin C on cancer cells.

Authors:  Seyeon Park
Journal:  Nutrients       Date:  2013-09-09       Impact factor: 5.717

8.  Phase I clinical trial to evaluate the safety, tolerability, and pharmacokinetics of high-dose intravenous ascorbic acid in patients with advanced cancer.

Authors:  Christopher M Stephenson; Robert D Levin; Thomas Spector; Christopher G Lis
Journal:  Cancer Chemother Pharmacol       Date:  2013-05-14       Impact factor: 3.333

9.  High-Dose Vitamin C Promotes Regression of Multiple Pulmonary Metastases Originating from Hepatocellular Carcinoma.

Authors:  Min-Seok Seo; Ja-Kyung Kim; Jae-Yong Shim
Journal:  Yonsei Med J       Date:  2015-09       Impact factor: 2.759

10.  Clinical experience with intravenous administration of ascorbic acid: achievable levels in blood for different states of inflammation and disease in cancer patients.

Authors:  Nina Mikirova; Joseph Casciari; Neil Riordan; Ronald Hunninghake
Journal:  J Transl Med       Date:  2013-08-15       Impact factor: 5.531

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