Literature DB >> 1461920

Brain tissue injury and blood-brain barrier opening induced by injection of LGE2 or PGE2.

J W Schmidley1, J Dadson, R S Iyer, R G Salomon.   

Abstract

The hypothesis that the accumulation of prostaglandin (PG)E2 during reperfusion of severely ischemic tissue contributes to a breakdown in the blood-brain barrier (BBB) was expanded to include a parallel role for levuglandins(LGs), gamma-ketoaldehydes produced by rearrangement of PGH2. LGE2 was shown to be more potent than PGE2 in causing breakdown of the BBB when injected intrahemispherically. Brain tissue necrosis was clearly evident with total doses of levuglandin as low as 100 nmole.

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Year:  1992        PMID： 1461920     DOI： 10.1016/0952-3278(92)90145-9

Source DB:  PubMed          Journal:  Prostaglandins Leukot Essent Fatty Acids        ISSN： 0952-3278            Impact factor:   4.006


  16 in total

1.  Total Synthesis Confirms the Molecular Structure Proposed for Oxidized Levuglandin D2.

Authors:  Yu-Shiuan Cheng; Wenyuan Yu; Yunfeng Xu; Robert G Salomon
Journal:  J Nat Prod       Date:  2017-02-14       Impact factor: 4.050

2.  Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Authors:  Sean S Davies; Eric J Brantley; Paul A Voziyan; Venkataraman Amarnath; Irene Zagol-Ikapitte; Olivier Boutaud; Billy G Hudson; John A Oates; L Jackson Roberts
Journal:  Biochemistry       Date:  2006-12-06       Impact factor: 3.162

3.  COX1 and COX2 expression in non-neuronal cellular compartments of the rhesus macaque brain during lentiviral infection.

Authors:  Candan Depboylu; Eberhard Weihe; Lee E Eiden
Journal:  Neurobiol Dis       Date:  2011-01-08       Impact factor: 5.996

4.  Molecular Structures of Isolevuglandin-Protein Cross-Links.

Authors:  Wenzhao Bi; Geeng-Fu Jang; Lei Zhang; John W Crabb; James Laird; Mikhail Linetsky; Robert G Salomon
Journal:  Chem Res Toxicol       Date:  2016-09-21       Impact factor: 3.739

Review 5.  Isolevuglandin adducts in disease.

Authors:  Robert G Salomon; Wenzhao Bi
Journal:  Antioxid Redox Signal       Date:  2015-02-18       Impact factor: 8.401

6.  Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts.

Authors:  Wei Li; James M Laird; Liang Lu; Sanjoy Roychowdhury; Laura E Nagy; Rong Zhou; John W Crabb; Robert G Salomon
Journal:  Free Radic Biol Med       Date:  2009-09-12       Impact factor: 7.376

7.  Inhibition of the prostaglandin receptor EP2 following status epilepticus reduces delayed mortality and brain inflammation.

Authors:  Jianxiong Jiang; Yi Quan; Thota Ganesh; Wendy A Pouliot; F Edward Dudek; Raymond Dingledine
Journal:  Proc Natl Acad Sci U S A       Date:  2013-02-11       Impact factor: 11.205

Review 8.  Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.

Authors:  Sean S Davies; Lilu Guo
Journal:  Chem Phys Lipids       Date:  2014-04-02       Impact factor: 3.329

9.  Cyclooxygenases-1 and -2 differentially modulate leukocyte recruitment into the inflamed brain.

Authors:  S-H Choi; S Aid; U Choi; F Bosetti
Journal:  Pharmacogenomics J       Date:  2009-12-29       Impact factor: 3.550

10.  Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP2 depletion.

Authors:  Osama F Harraz; Thomas A Longden; Fabrice Dabertrand; David Hill-Eubanks; Mark T Nelson
Journal:  Proc Natl Acad Sci U S A       Date:  2018-03-26       Impact factor: 11.205
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