Literature DB >> 14618272

DNA fragmentation in leukocytes following subacute low-dose nerve agent exposure.

J R Moffett1, R A Price, S M Anderson, M L Sipos, A V Moran, F C Tortella, J R Dave.   

Abstract

The objective of the present study was to determine levels of DNA fragmentation in blood leukocytes from guinea pigs by single-cell gel electrophoresis (comet assay) after exposure to the chemical warfare nerve agent (CWNA), soman, at doses ranging from 0.1 LD50 to 0.4 LD50, once per day for either 5 or 10 days. Post-exposure recovery periods ranged from 0 to 17 days. Leukocytes were imaged from each animal, and the images analyzed by computer. Data obtained for exposure to soman demonstrated significant increases in DNA fragmentation in circulating leukocytes in CWNA-treated guinea pigs compared with saline-injected control animals at all doses and time points examined. Notably, significantly increased DNA fragmentation was observed in leukocytes 17 days after cessation of soman exposure. Our findings demonstrate that leukocyte DNA fragmentation assays may provide a sensitive biomarker for low-dose CWNA exposure.

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Year:  2003        PMID： 14618272     DOI： 10.1007/s00018-003-3238-x

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.261


  56 in total

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3.  Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent.

Authors:  R Dumaine; J A Towbin; P Brugada; M Vatta; D V Nesterenko; V V Nesterenko; J Brugada; R Brugada; C Antzelevitch
Journal:  Circ Res       Date:  1999-10-29       Impact factor: 17.367

4.  Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome.

Authors:  A J Moss; J L Robinson; L Gessman; R Gillespie; W Zareba; P J Schwartz; G M Vincent; J Benhorin; E L Heilbron; J A Towbin; S G Priori; C Napolitano; L Zhang; A Medina; M L Andrews; K Timothy
Journal:  Am J Cardiol       Date:  1999-10-15       Impact factor: 2.778

5.  Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias.

Authors:  P J Schwartz; S G Priori; C Spazzolini; A J Moss; G M Vincent; C Napolitano; I Denjoy; P Guicheney; G Breithardt; M T Keating; J A Towbin; A H Beggs; P Brink; A A Wilde; L Toivonen; W Zareba; J L Robinson; K W Timothy; V Corfield; D Wattanasirichaigoon; C Corbett; W Haverkamp; E Schulze-Bahr; M H Lehmann; K Schwartz; P Coumel; R Bloise
Journal:  Circulation       Date:  2001-01-02       Impact factor: 29.690

6.  Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG.

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Journal:  J Cardiovasc Electrophysiol       Date:  2005-01

7.  Sudden death associated with short-QT syndrome linked to mutations in HERG.

Authors:  Ramon Brugada; Kui Hong; Robert Dumaine; Jonathan Cordeiro; Fiorenzo Gaita; Martin Borggrefe; Teresa M Menendez; Josep Brugada; Guido D Pollevick; Christian Wolpert; Elena Burashnikov; Kiyotaka Matsuo; Yue Sheng Wu; Alejandra Guerchicoff; Francesca Bianchi; Carla Giustetto; Rainer Schimpf; Pedro Brugada; Charles Antzelevitch
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Review 8.  Recommendations for physical activity and recreational sports participation for young patients with genetic cardiovascular diseases.

Authors:  Barry J Maron; Bernard R Chaitman; Michael J Ackerman; Antonio Bayés de Luna; Domenico Corrado; Jane E Crosson; Barbara J Deal; David J Driscoll; N A Mark Estes; Claudio Gil S Araújo; David H Liang; Matthew J Mitten; Robert J Myerburg; Antonio Pelliccia; Paul D Thompson; Jeffrey A Towbin; Steven P Van Camp
Journal:  Circulation       Date:  2004-06-08       Impact factor: 29.690

9.  ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome.

Authors:  A J Moss; W Zareba; J Benhorin; E H Locati; W J Hall; J L Robinson; P J Schwartz; J A Towbin; G M Vincent; M H Lehmann
Journal:  Circulation       Date:  1995-11-15       Impact factor: 29.690

10.  Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers.

Authors:  Silvia G Priori; Carlo Napolitano; Peter J Schwartz; Massimiliano Grillo; Raffaella Bloise; Elena Ronchetti; Cinzia Moncalvo; Chiara Tulipani; Alessia Veia; Georgia Bottelli; Janni Nastoli
Journal:  JAMA       Date:  2004-09-15       Impact factor: 56.272
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  1 in total

1.  Atmospheric Deposition-Carried Zn and Cd from a Zinc Smelter and Their Effects on Soil Microflora as Revealed by 16S rDNA.

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Journal:  Sci Rep       Date:  2016-12-13       Impact factor: 4.379
  1 in total

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